Steven J Charlton
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Explore the profile of Steven J Charlton including associated specialties, affiliations and a list of published articles.
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64
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Recent Articles
1.
Casella B, Farmer J, Nesheva D, Williams H, Charlton S, Holliday N, et al.
J Med Chem
. 2023 Jul;
66(18):12911-12930.
PMID: 37523859
The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a potential strategy in the treatment of several pulmonary diseases and cancers. The complexity of endogenous chemokine...
2.
Yen H, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, et al.
Nat Chem
. 2022 Nov;
14(12):1375-1382.
PMID: 36357787
G-protein-coupled receptors signal through cognate G proteins. Despite the widespread importance of these receptors, their regulatory mechanisms for G-protein selectivity are not fully understood. Here we present a native mass...
3.
Sutcliffe K, Corey R, Alhosan N, Cavallo D, Groom S, Santiago M, et al.
Adv Drug Alcohol Res
. 2022 Aug;
2.
PMID: 35909438
Overdose deaths from fentanyl have reached epidemic proportions in the USA and are increasing worldwide. Fentanyl is a potent opioid agonist that is less well reversed by naloxone than morphine....
4.
Sykes D, Jimenez-Roses M, Reilly J, Fairhurst R, Charlton S, Veprintsev D
Pharmacol Res Perspect
. 2022 Jun;
10(4):e00978.
PMID: 35762357
In this study, we report the β -adrenoceptor binding kinetics of several clinically relevant β -adrenoceptor (β AR) agonists and antagonists. [ H]-DHA was used to label CHO-β AR for...
5.
Roberts M, May L, Keen A, Liu B, Lam T, Charlton S, et al.
Front Pharmacol
. 2021 May;
12:669227.
PMID: 33995100
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue...
6.
Fyfe T, Kellam B, Sykes D, Capuano B, Scammells P, Lane J, et al.
J Med Chem
. 2019 Oct;
62(21):9488-9520.
PMID: 31580666
Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side effects (EPSs) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine...
7.
Sykes D, Jain P, Charlton S
Mol Pharmacol
. 2019 Aug;
96(3):378-392.
PMID: 31436538
An increased appreciation of the importance of optimizing drug-binding kinetics has lead to the development of various techniques for measuring the kinetics of unlabeled compounds. One approach is the competition-association...
8.
Koziczak-Holbro M, Rigel D, Dumotier B, Sykes D, Tsao J, Nguyen N, et al.
J Pharmacol Exp Ther
. 2019 Mar;
369(2):188-199.
PMID: 30819762
The anabolic effects of -adrenoceptor ( -AR) agonists on skeletal muscle have been demonstrated in various species. However, the clinical use of -AR agonists for skeletal muscle wasting conditions has...
9.
Rosethorne E, Charlton S
J Exp Pharmacol
. 2018 Dec;
10:75-85.
PMID: 30568517
Airway remodeling is a characteristic of many chronic respiratory diseases and occurs when there are significant changes to the architecture of the small and large airways leading to progressive loss...
10.
Civciristov S, Ellisdon A, Suderman R, Pon C, Evans B, Kleifeld O, et al.
Sci Signal
. 2018 Oct;
11(551).
PMID: 30301787
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins, participate in nearly all physiological processes, and are the targets of 30% of marketed drugs. Typically, nanomolar...