Steven I Reed
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Explore the profile of Steven I Reed including associated specialties, affiliations and a list of published articles.
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56
Citations
2509
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Recent Articles
1.
Giraldez S, Tamayo P, Wineinger N, Kim W, Reed S
iScience
. 2019 Sep;
19:850-859.
PMID: 31513970
Cyclin E, a key cell cycle regulatory protein, has been linked to oncogenesis when dysregulated. We have previously shown that overexpression of cyclin E causes replication stress, leading to failure...
2.
Galindo-Moreno M, Giraldez S, Limon-Mortes M, Belmonte-Fernandez A, Reed S, Saez C, et al.
FASEB J
. 2019 Jul;
33(10):11420-11430.
PMID: 31337255
Eukaryotic cells have developed sophisticated mechanisms to ensure the integrity of the genome and prevent the transmission of altered genetic information to daughter cells. If this control system fails, accumulation...
3.
Ekholm-Reed S, Baker R, Campos A, Stouffer D, Henze M, Wolf D, et al.
Commun Biol
. 2019 Apr;
2:125.
PMID: 30963113
Mutations in the gene are associated with early onset Parkinsonism. The mouse, however, does not exhibit neurodegeneration or other Parkinson's disease (PD) phenotypes. Previously, we discovered that translation of Mcl-1,...
4.
Tat J, Loriot C, Henze M, Spruck C, Felding B, Reed S
Oncotarget
. 2018 Feb;
8(70):114911-114923.
PMID: 29383129
The cyclin-dependent kinase-interacting proteins Cyclin-dependent Kinase Subunit 1 and 2 (CKS1 and 2) are frequently overexpressed in cancer and linked to increased aggressiveness and poor prognoses. We previously showed that...
5.
Teixeira L, Reed S
Adv Exp Med Biol
. 2018 Jan;
1042:527-547.
PMID: 29357072
Precise replication of genetic material and its equal distribution to daughter cells are essential to maintain genome stability. In eukaryotes, chromosome replication and segregation are temporally uncoupled, occurring in distinct...
6.
Mu R, Tat J, Zamudio R, Zhang Y, Yates 3rd J, Kumagai A, et al.
Mol Cell Biol
. 2017 Jul;
37(20).
PMID: 28739856
CKS proteins are small (9-kDa) polypeptides that bind to a subset of the cyclin-dependent kinases. The two paralogs expressed in mammals, Cks1 and Cks2, share an overlapping function that is...
7.
French M, Klosowiak J, Aslanian A, Reed S, Yates 3rd J, Hunter T
J Biol Chem
. 2017 May;
292(25):10398-10413.
PMID: 28461335
omologous to 6AP -erminal (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester...
8.
9.
Teixeira L, Wang X, Li Y, Ekholm-Reed S, Wu X, Wang P, et al.
Curr Biol
. 2015 May;
25(10):1327-33.
PMID: 25959964
Cell-cycle progression is regulated by the cyclin-dependent kinase (Cdk) family of protein kinases, so named because their activation depends on association with regulatory subunits known as cyclins. Cyclin E normally...
10.
Ekholm-Reed S, Goldberg M, Schlossmacher M, Reed S
Mol Cell Biol
. 2013 Jul;
33(18):3627-43.
PMID: 23858059
Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons resulting in motor dysfunction. While most PD is sporadic in nature, a significant subset can be linked to...