Steven I Reed
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Explore the profile of Steven I Reed including associated specialties, affiliations and a list of published articles.
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56
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2509
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Recent Articles
11.
Pan Y, Sun M, Wohlschlegel J, Reed S
Eukaryot Cell
. 2013 Jul;
12(9):1192-201.
PMID: 23825181
Cks1 was originally identified based on genetic interactions with CDC28, the gene that encodes Cdk1 in the budding yeast Saccharomyces cerevisiae. Subsequent work has shown that Cks1 binds Cdc28 and...
12.
Teixeira L, Reed S
Annu Rev Biochem
. 2013 Mar;
82:387-414.
PMID: 23495935
The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute a critical component...
13.
Bhaskaran N, van Drogen F, Ng H, Kumar R, Ekholm-Reed S, Peter M, et al.
Mol Cell Biol
. 2012 Oct;
33(1):85-97.
PMID: 23109421
Cyclin E1, an activator of cyclin-dependent kinase 2 (Cdk2) that promotes replicative functions, is normally expressed periodically within the mammalian cell cycle, peaking at the G(1)-S-phase transition. This periodicity is...
14.
Simmons Kovacs L, Mayhew M, Orlando D, Jin Y, Li Q, Huang C, et al.
Mol Cell
. 2012 Feb;
45(5):669-79.
PMID: 22306294
During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex, incorporating multiple G1,...
15.
16.
Liberal V, Martinsson-Ahlzen H, Liberal J, Spruck C, Widschwendter M, McGowan C, et al.
Proc Natl Acad Sci U S A
. 2011 Jun;
109(8):2754-9.
PMID: 21697511
Cyclin-dependent kinase subunit (Cks) proteins are small cyclin-dependent kinase-interacting proteins that are frequently overexpressed in breast cancer, as well as in a broad spectrum of other human malignancies. However, the...
17.
Liberal V, De Miguel M, Henze M, Nistal M, Reed S
Cell Cycle
. 2010 Oct;
9(20):4222-7.
PMID: 20962587
Cyclin E is a key component of the cell cycle regulatory machinery, contributing to the activation of Cdk2 and the control of cell cycle progression at several stages. Cyclin E...
18.
Chaves S, Baskerville C, Yu V, Reed S
Mol Cell Biol
. 2010 Sep;
30(22):5284-94.
PMID: 20855529
Cks1, Cdk1 (Cdc28), and the proteasome are required for efficient transcriptional induction of GAL1 and other genes in Saccharomyces cerevisiae. We show here that one function of these proteins is...
19.
Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry
Chuang L, Teixeira L, Wohlschlegel J, Henze M, Yates J, Mendez J, et al.
Mol Cell
. 2009 Aug;
35(2):206-16.
PMID: 19647517
Cyclin E has been shown to have a role in pre-replication complex (Pre-RC) assembly in cells re-entering the cell cycle from quiescence. The assembly of the pre-RC, which involves the...
20.
Martinsson-Ahlzen H, Liberal V, Grunenfelder B, Chaves S, Spruck C, Reed S
Mol Cell Biol
. 2008 Jul;
28(18):5698-709.
PMID: 18625720
Cks proteins associate with cyclin-dependent kinases and have therefore been assumed to play a direct role in cell cycle regulation. Mammals have two paralogs, Cks1 and Cks2, and individually deleting...