Steven H Young
Overview
Explore the profile of Steven H Young including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
841
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Recent Articles
1.
Chang J, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, et al.
J Biol Chem
. 2017 Apr;
292(23):9523-9539.
PMID: 28408623
Although PKC-mediated phosphorylation of protein kinase D1 (PKD1) has been extensively characterized, little is known about PKD1 regulation by other upstream kinases. Here we report that stimulation of epithelial or...
2.
Hao F, Xu Q, Zhao Y, Stevens J, Young S, Sinnett-Smith J, et al.
Mol Cancer Res
. 2017 Apr;
15(7):929-941.
PMID: 28360038
We examined the impact of crosstalk between the insulin receptor and G protein-coupled receptor (GPCR) signaling pathways on the regulation of Yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in...
3.
Wang J, Sinnett-Smith J, Stevens J, Young S, Rozengurt E
J Biol Chem
. 2016 Jul;
291(34):17988-8005.
PMID: 27369082
We examined the regulation of Yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in intestinal epithelial cells. Our results show that stimulation of intestinal epithelial IEC-18 cells with the G...
4.
Wang J, Han L, Sinnett-Smith J, Han L, Stevens J, Rozengurt N, et al.
Am J Physiol Cell Physiol
. 2016 Jan;
310(7):C542-57.
PMID: 26739494
Given the fundamental role of β-catenin signaling in intestinal epithelial cell proliferation and the growth-promoting function of protein kinase D1 (PKD1) in these cells, we hypothesized that PKDs mediate cross...
5.
Young S, Rey O, Rozengurt E
Biochem Biophys Res Commun
. 2015 Oct;
467(1):1-6.
PMID: 26431875
The extracellular Ca(2+)-sensing receptor (CaSR) is an allosteric protein that responds to changes in the extracellular concentration of Ca(2+) ([Ca(2+)]e) and aromatic amino acids with the production of different patterns...
6.
Chang H, Young S, Sinnett-Smith J, Chou C, Moro A, Hertzer K, et al.
Am J Physiol Cell Physiol
. 2015 Aug;
309(10):C639-49.
PMID: 26310818
Obesity, a known risk factor for pancreatic cancer, is associated with inflammation and insulin resistance. Proinflammatory prostaglandin E2 (PGE2) and elevated insulin-like growth factor type 1 (IGF-1), related to insulin...
7.
Soares H, Ming M, Mellon M, Young S, Han L, Sinnet-Smith J, et al.
Mol Cancer Ther
. 2015 Feb;
14(4):1014-23.
PMID: 25673820
The PI3K/AKT/mTOR pathway, which is aberrantly stimulated in many cancer cells, has emerged as a target for therapy. However, mTORC1/S6K also mediates negative feedback loops that attenuate upstream signaling. Suppression...
8.
Ming M, Sinnett-Smith J, Wang J, Soares H, Young S, Eibl G, et al.
PLoS One
. 2014 Dec;
9(12):e114573.
PMID: 25493642
Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti-proliferative and chemopreventive properties. Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with...
9.
Sinnett-Smith J, Ni Y, Wang J, Ming M, Young S, Rozengurt E
Am J Physiol Cell Physiol
. 2014 Mar;
306(10):C961-71.
PMID: 24647541
We examined whether class IIa histone deacetylases (HDACs) play a role in mitogenic signaling mediated by protein kinase D1 (PKD1) in IEC-18 intestinal epithelial cells. Our results show that class...
10.
Young S, Rey O, Sinnett-Smith J, Rozengurt E
Am J Physiol Cell Physiol
. 2013 Dec;
306(3):C298-306.
PMID: 24336654
To clarify the mechanism(s) underlying intracellular Ca(2+) concentration ([Ca(2+)]i) oscillations induced by an elevation in extracellular Ca(2+) concentration ([Ca(2+)]e) via the extracellular Ca(2+)-sensing receptor (CaR), we analyzed the pattern of...