Steven E McKenzie
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Explore the profile of Steven E McKenzie including associated specialties, affiliations and a list of published articles.
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75
Citations
1662
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Recent Articles
1.
Boelig R, Foecke Munden E, Zhan T, McKenzie S, Kraft W
Clin Transl Sci
. 2025 Mar;
18(3):e70167.
PMID: 40040304
Low-dose aspirin is recommended for prevention of hypertensive disorders of pregnancy (HDP) and preterm birth (PTB) in high-risk pregnancies. There is limited data on factors impacting aspirin response in pregnancy....
2.
Wurtzel J, Gray B, Pak K, Zhao X, Ma P, McKenzie S, et al.
J Thromb Haemost
. 2024 Oct;
23(1):108-122.
PMID: 39423958
Background: Phosphatidylserine (PS) is a procoagulant phospholipid enriched on surfaces of activated vascular cells including platelets, endothelium, monocytes, and microvesicles. As a molecular driver of thrombosis accessible to drug blockade,...
3.
Leung H, Ahmadi Z, Lee B, Casey J, Ratnasingam S, McKenzie S, et al.
Blood Adv
. 2024 Sep;
8(22):5744-5752.
PMID: 39293086
Current guidelines for treating vaccine-induced immune thrombotic thrombocytopenia (VITT) recommend nonheparin anticoagulants and IV immunoglobulin (IVIg). However, the efficacy of these treatments remains uncertain due to case studies involving small...
4.
A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity
Han X, Knauss E, Fuente M, Li W, Conlon R, LePage D, et al.
J Thromb Haemost
. 2024 Mar;
22(6):1715-1726.
PMID: 38508397
Background: Protease-activated receptor 4 (PAR4) mediates thrombin signaling on platelets and other cells. Our recent structural studies demonstrated that a single nucleotide polymorphism in extracellular loop 3 and PAR4-P310L (rs2227376)...
5.
Kostyak J, McKenzie S, Naik U
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203381
Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase that is ubiquitously expressed in nucleated cells and is responsible for the activation of multiple mitogen-activated protein kinases (MAPK) to regulate...
6.
Wurtzel J, Lazar S, Askari S, Zhao X, Severa J, Ayombil F, et al.
Blood Adv
. 2024 Jan;
8(6):1550-1566.
PMID: 38163324
Mechanisms of proteostasis in anucleate circulating platelets are unknown and may regulate platelet function. We investigated the hypothesis that plasma-borne growth factors/hormones (GFHs) maintain constitutive translation in circulating platelets to...
7.
Boelig R, Kaushal G, Rochani A, McKenzie S, Kraft W
Am J Obstet Gynecol
. 2023 Dec;
231(3):344.e1-344.e16.
PMID: 38145726
Background: Low dose aspirin is recommended for prevention of preeclampsia, however there is not consensus on the appropriate dose. Pregnancy specific changes have the potential to impact the pharmacology of...
8.
Han X, Knauss E, Fuente M, Li W, Conlon R, LePage D, et al.
bioRxiv
. 2023 Dec;
PMID: 38077081
Background: Protease activated receptor 4 (PAR4) mediates thrombin signaling on platelets and other cells. Our recent structural studies demonstrated a single nucleotide polymorphism in extracellular loop 3 (ECL3), PAR4-P310L (rs2227376)...
9.
Aid M, Stephenson K, Collier A, Nkolola J, Michael J, McKenzie S, et al.
Nat Commun
. 2023 Oct;
14(1):6703.
PMID: 37872311
Thrombosis with thrombocytopenia syndrome (TTS) is a rare but potentially severe adverse event following immunization with adenovirus vector-based COVID-19 vaccines such as Ad26.COV2.S (Janssen) and ChAdOx1 (AstraZeneca). However, no case...
10.
Denorme F, Armstrong N, Stoller M, Portier I, Tugolukova E, Tanner R, et al.
J Clin Invest
. 2023 Jul;
133(18).
PMID: 37471144
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in...