James V Michael
Overview
Explore the profile of James V Michael including associated specialties, affiliations and a list of published articles.
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20
Citations
375
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Recent Articles
1.
Wurtzel J, Lazar S, Askari S, Zhao X, Severa J, Ayombil F, et al.
Blood Adv
. 2024 Jan;
8(6):1550-1566.
PMID: 38163324
Mechanisms of proteostasis in anucleate circulating platelets are unknown and may regulate platelet function. We investigated the hypothesis that plasma-borne growth factors/hormones (GFHs) maintain constitutive translation in circulating platelets to...
2.
Aid M, Stephenson K, Collier A, Nkolola J, Michael J, McKenzie S, et al.
Nat Commun
. 2023 Oct;
14(1):6703.
PMID: 37872311
Thrombosis with thrombocytopenia syndrome (TTS) is a rare but potentially severe adverse event following immunization with adenovirus vector-based COVID-19 vaccines such as Ad26.COV2.S (Janssen) and ChAdOx1 (AstraZeneca). However, no case...
3.
Renna S, Zhao X, Kunapuli S, Ma P, Holinstat M, Boxer M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(10):1808-1817.
PMID: 37345522
Background: Heparin-induced thrombocytopenia (HIT) is a major concern for all individuals that undergo cardiac bypass surgeries or require prolonged heparin exposure. HIT is a life- and limb-threatening adverse drug reaction...
4.
Renna S, McKenzie S, Michael J
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37176005
Protease-activated receptors (PARs) are a class of integral membrane proteins that are cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and promote activation. PARs...
5.
Zhao X, Cooper M, Michael J, Yarman Y, Baltz A, Chuprun J, et al.
Blood Adv
. 2022 Jul;
6(15):4524-4536.
PMID: 35793439
The critical role of G protein-coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for >3 decades. Targeting GRK2 has therefore been extensively studied as a...
6.
Huynh A, Arnold D, Michael J, Clare R, Smith J, Daka M, et al.
Blood Adv
. 2022 Apr;
7(2):246-250.
PMID: 35377937
No abstract available.
7.
Renna S, Michael J, Kong X, Ma L, Ma P, Nieman M, et al.
J Thromb Haemost
. 2022 Feb;
20(5):1236-1247.
PMID: 35152546
Background: Human and mouse platelets both express protease-activated receptor (PAR) 4 but sequence alignment reveals differences in several functional domains. These differences may result in functional disparities between the receptors...
8.
Downes K, Zhao X, Gleadall N, McKinney H, Kempster C, Batista J, et al.
Blood Adv
. 2021 Sep;
6(7):2319-2330.
PMID: 34581777
The interindividual variation in the functional response of platelets to activation by agonists is heritable. Genome-wide association studies (GWASs) of quantitative measures of platelet function have identified fewer than 20...
9.
Patel P, Michael J, Naik U, McKenzie S
J Thromb Haemost
. 2021 Feb;
19(5):1149-1160.
PMID: 33587783
Sepsis and autoimmune diseases remain major causes of morbidity and mortality. The last decade has seen a new appreciation of platelets in host defense, in both immunity and thrombosis. Platelets...
10.
Nayak A, Shah S, Michael J, Deshpande D
Front Physiol
. 2019 Aug;
10:884.
PMID: 31379597
Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and corticosteroids, and more recently, monoclonal antibody...