Steven A Roberts
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Explore the profile of Steven A Roberts including associated specialties, affiliations and a list of published articles.
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74
Citations
6270
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Recent Articles
11.
Mertz T, Rice-Reynolds E, Nguyen L, Wood A, Bray N, Mitchell D, et al.
bioRxiv
. 2023 Apr;
PMID: 37066362
The cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to...
12.
Bohm K, Morledge-Hampton B, Stevison S, Mao P, Roberts S, Wyrick J
Proc Natl Acad Sci U S A
. 2023 Feb;
120(10):e2216907120.
PMID: 36853943
Ultraviolet (UV) light induces different classes of mutagenic photoproducts in DNA, namely cyclobutane pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and atypical thymine-adenine photoproducts (TA-PPs). CPD formation is modulated by nucleosomes...
13.
Talukdar P, Crockett T, Gloss L, Huynh S, Roberts S, Turner K, et al.
Front Microbiol
. 2023 Jan;
13:1062464.
PMID: 36619995
Oxidative damage to DNA is a significant source of mutations in living organisms. While DNA damage must be repaired to maintain the integrity of the genome and cell survival, errors...
14.
Mertz T, Collins C, Dennis M, Coxon M, Roberts S
Annu Rev Genet
. 2022 Aug;
56:229-252.
PMID: 36028227
The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation rates accelerate carcinogenesis and hinder the development of long-lasting therapeutics....
15.
Hanscom T, Woodward N, Batorsky R, Brown A, Roberts S, McVey M
Nucleic Acids Res
. 2022 Jul;
50(13):7465-7478.
PMID: 35819195
Alternative end joining (alt-EJ) mechanisms, such as polymerase theta-mediated end joining, are increasingly recognized as important contributors to inaccurate double-strand break repair. We previously proposed an alt-EJ model whereby short...
16.
Al-Soodani A, Wu X, Kelp N, Brown A, Roberts S, Her C
Genes (Basel)
. 2022 Apr;
13(4).
PMID: 35456479
Inappropriate repair of DNA double-strand breaks (DSBs) leads to genomic instability, cell death, or malignant transformation. Cells minimize these detrimental effects by selectively activating suitable DSB repair pathways in accordance...
17.
Roberts S, Lee C, Singh S, Agrawal N
Membranes (Basel)
. 2022 Mar;
12(3).
PMID: 35323794
The wide-scale use of liposomal delivery systems is challenged by difficulties in obtaining potent liposomal suspensions. Passive and active loading strategies have been proposed to formulate drug encapsulated liposomes but...
18.
Antony J, Roberts S, Wyrick J, Hinz J
DNA Repair (Amst)
. 2021 Nov;
109:103257.
PMID: 34847381
Cas9 targets DNA during genome editing by forming an RNA:DNA heteroduplex (R-loop) between the Cas9-bound guide RNA and the targeted DNA strand. We have recently demonstrated that R-loop formation by...
19.
Bonilla B, Brown A, Hengel S, Rapchak K, Mitchell D, Pressimone C, et al.
Elife
. 2021 Nov;
10.
PMID: 34723799
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast,...
20.
Brown A, Collins C, Thompson S, Coxon M, Mertz T, Roberts S
Sci Rep
. 2021 Oct;
11(1):21008.
PMID: 34697369
The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed...