Steve P Gygi
Overview
Explore the profile of Steve P Gygi including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
1342
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Recent Articles
1.
Liang J, Vitale T, Zhang X, Jackson T, Yu D, Jedrychowski M, et al.
Nat Cancer
. 2025 Jan;
6(2):323-337.
PMID: 39824999
Cancer cells frequently rewire their metabolism to support proliferation and evade immune surveillance, but little is known about metabolic targets that could increase immune surveillance. Here we show a specific...
2.
Nash B, Gregory W, White R, Protasio A, Gygi S, Selkirk M, et al.
Front Parasitol
. 2025 Jan;
2():1078443.
PMID: 39816813
The genus contains parasitic nematodes capable of infecting a wide range of hosts including mammals, birds and reptiles. Like other helminths, secretes a complex mixture of bioactive molecules capable of...
3.
Bernardo G, Prado M, Dashtmian A, Favaro M, Mauri S, Borsetto A, et al.
Pharmacol Res
. 2024 Nov;
210:107484.
PMID: 39486496
Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal...
4.
Klickstein J, Johnson M, Antonoudiou P, Maguire J, Paulo J, Gygi S, et al.
Stem Cell Reports
. 2024 Feb;
19(3):366-382.
PMID: 38335961
Mutations in the AAA+ ATPase p97 cause multisystem proteinopathy 1, which includes amyotrophic lateral sclerosis; however, the pathogenic mechanisms that contribute to motor neuron loss remain obscure. Here, we use...
5.
Ahlstedt B, Ganji R, Mukkavalli S, Paulo J, Gygi S, Raman M
EMBO Rep
. 2024 Jan;
25(2):672-703.
PMID: 38177917
ER protein homeostasis (proteostasis) is essential for proper folding and maturation of proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of misfolded or aberrant...
6.
Liang J, Vitale T, Zhang X, Jackson T, Yu D, Jedrychowski M, et al.
bioRxiv
. 2023 Oct;
PMID: 37873273
Targeting of specific metabolic pathways in tumor cells has the potential to sensitize them to immune-mediated attack. Here we provide evidence for a specific means of mitochondrial respiratory Complex I...
7.
Liang J, Yu D, Luo C, Bennett C, Jedrychowski M, Gygi S, et al.
Nat Commun
. 2023 Jun;
14(1):3251.
PMID: 37277330
While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer recur. Here we provide data indicating that epigenetic suppression of PGC1α defines an aggressive subset...
8.
Ganji R, Paulo J, Xi Y, Kline I, Zhu J, Clemen C, et al.
Nat Commun
. 2023 Feb;
14(1):638.
PMID: 36746962
The intimate association between the endoplasmic reticulum (ER) and mitochondrial membranes at ER-Mitochondria contact sites (ERMCS) is a platform for critical cellular processes, particularly lipid synthesis. How contacts are remodeled...
9.
Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, et al.
Cell Rep
. 2019 Jun;
27(13):3972-3987.e6.
PMID: 31242427
Cancer extracellular vesicles (EVs) are highly heterogeneous, which impedes our understanding of their function as intercellular communication agents and biomarkers. To deconstruct this heterogeneity, we analyzed extracellular RNAs (exRNAs) and...
10.
Balsa E, Soustek M, Thomas A, Cogliati S, Garcia-Poyatos C, Martin-Garcia E, et al.
Mol Cell
. 2019 Apr;
74(5):877-890.e6.
PMID: 31023583
Endoplasmic reticulum (ER) stress and unfolded protein response are energetically challenging under nutrient stress conditions. However, the regulatory mechanisms that control the energetic demand under nutrient and ER stress are...