Steve Lefever
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Explore the profile of Steve Lefever including associated specialties, affiliations and a list of published articles.
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54
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1902
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Recent Articles
1.
Godazandeh K, Van Olmen L, Van Oudenhove L, Lefever S, Bogaert C, Fant B
Methods Cell Biol
. 2024 Mar;
183:161-186.
PMID: 38548411
Next to conventional cancer therapies, immunotherapies such as immune checkpoint inhibitors have broadened the cancer treatment landscape over the past decades. Recent advances in next generation sequencing and bioinformatics technologies...
2.
Lybaert L, Lefever S, Fant B, Smits E, De Geest B, Breckpot K, et al.
Cancer Cell
. 2022 Nov;
41(1):15-40.
PMID: 36368320
A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a promising strategy that aims at targeting...
3.
Decock A, Creytens D, Lefever S, Van der Meulen J, Anckaert J, De Ganck A, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232302
We assess the performance of mRNA capture sequencing to identify fusion transcripts in FFPE tissue of different sarcoma types, followed by RT-qPCR confirmation. To validate our workflow, six positive control...
4.
Wils G, Helsmoortel C, Volders P, Vereecke I, Milazzo M, Vandesompele J, et al.
Mol Diagn Ther
. 2022 May;
26(4):411-419.
PMID: 35633488
Introduction: Next-generation sequencing applications are becoming indispensable for clinical diagnostics. These experiments require numerous wet- and dry-laboratory steps, each one increasing the probability of a sample swap or contamination. Therefore,...
5.
Schoofs K, Philippron A, Avila Cobos F, Koster J, Lefever S, Anckaert J, et al.
Sci Data
. 2022 Mar;
9(1):86.
PMID: 35288573
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers...
6.
Vromman M, Yigit N, Verniers K, Lefever S, Vandesompele J, Volders P
Curr Protoc
. 2021 Jul;
1(7):e181.
PMID: 34232572
Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that have been shown to play a role in normal development, homeostasis, and disease, including cancer. CircRNAs are formed through...
7.
Lorenzi L, Chiu H, Avila Cobos F, Gross S, Volders P, Cannoodt R, et al.
Nat Biotechnol
. 2021 Jun;
39(11):1467.
PMID: 34183863
No abstract available.
8.
Lorenzi L, Chiu H, Avila Cobos F, Gross S, Volders P, Cannoodt R, et al.
Nat Biotechnol
. 2021 Jun;
39(11):1453-1465.
PMID: 34140680
Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are derived almost exclusively from small and polyadenylated RNAs. Here we present a more comprehensive atlas of the...
9.
Hulstaert E, Morlion A, Avila Cobos F, Verniers K, Nuytens J, Vanden Eynde E, et al.
Cell Rep
. 2020 Dec;
33(13):108552.
PMID: 33378673
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of...
10.
Mus L, Van Haver S, Popovic M, Trypsteen W, Lefever S, Zeltner N, et al.
Genes Chromosomes Cancer
. 2020 Dec;
60(4):272-281.
PMID: 33336840
Human embryonic stem cells (hESCs) and embryonal tumors share a number of common features, including a compromised G1/S checkpoint. Consequently, these rapidly dividing hESCs and cancer cells undergo elevated levels...