Steve Gerondakis
Overview
Explore the profile of Steve Gerondakis including associated specialties, affiliations and a list of published articles.
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61
Citations
2250
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Recent Articles
1.
Zaini A, Fulford T, Grumont R, Runting J, Rodrigues G, Ng J, et al.
Front Immunol
. 2021 Jul;
12:667922.
PMID: 34194431
Group 2 innate lymphoid cells (ILC2s) are emerging as important cellular regulators of homeostatic and disease-associated immune processes. The cytokine interleukin-33 (IL-33) promotes ILC2-dependent inflammation and immunity, with IL-33 having...
2.
Fulford T, Grumont R, Wirasinha R, Ellis D, Barugahare A, Turner S, et al.
Eur J Immunol
. 2021 May;
51(8):2006-2026.
PMID: 33960413
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg defect in c-Rel-deficient...
3.
Mancini M, Caignard G, Charbonneau B, Dumaine A, Wu N, Leiva-Torres G, et al.
J Immunol
. 2019 Jan;
202(5):1479-1493.
PMID: 30683700
Herpes simplex encephalitis (HSE), caused by HSV type 1 (HSV-1) infection, is an acute neuroinflammatory condition of the CNS and remains the most common type of sporadic viral encephalitis worldwide....
4.
Lancaster G, Langley K, Berglund N, Kammoun H, Reibe S, Estevez E, et al.
Cell Metab
. 2018 Apr;
27(5):1096-1110.e5.
PMID: 29681442
Chronic inflammation is a hallmark of obesity and is linked to the development of numerous diseases. The activation of toll-like receptor 4 (TLR4) by long-chain saturated fatty acids (lcSFAs) is...
5.
OReilly L, Putoczki T, Mielke L, Low J, Lin A, Preaudet A, et al.
Immunity
. 2018 Mar;
48(3):570-583.e8.
PMID: 29562203
Polymorphisms in NFKB1 that diminish its expression have been linked to human inflammatory diseases and increased risk for epithelial cancers. The underlying mechanisms are unknown, and the link is perplexing...
6.
Gerondakis S, Fulford T, Messina N, Grumont R
Nat Immunol
. 2017 Sep;
18(10):1173.
PMID: 28926541
No abstract available.
7.
Martinic M, Caminschi I, OKeeffe M, Thinnes T, Grumont R, Gerondakis S, et al.
J Immunol
. 2017 Feb;
198(7):2649-2660.
PMID: 28202617
Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Although studies have addressed the role of NOD proteins in innate immune...
8.
Messina N, Fulford T, OReilly L, Loh W, Motyer J, Ellis D, et al.
J Autoimmun
. 2016 Apr;
70:52-62.
PMID: 27068879
The properties of CD4(+) regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show...
9.
de Valle E, Grigoriadis G, OReilly L, Willis S, Maxwell M, Corcoran L, et al.
J Exp Med
. 2016 Mar;
213(4):621-41.
PMID: 27022143
We examined the role of NFκB1 in the homeostasis and function of peripheral follicular (Fo) B cells. Aging mice lacking NFκB1 (Nfκb1(-/-)) develop lymphoproliferative and multiorgan autoimmune disease attributed in...
10.
Fulford T, Ellis D, Gerondakis S
Prog Mol Biol Transl Sci
. 2015 Nov;
136:57-67.
PMID: 26615092
The nuclear factor of kappaB (NF-κB) pathway has emerged as an important regulator of gene expression in CD4(+) regulatory T cells. Here, we review various aspects of the roles NF-κB...