Raffi Gugasyan
Overview
Explore the profile of Raffi Gugasyan including associated specialties, affiliations and a list of published articles.
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20
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1072
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Recent Articles
1.
Delgado-Diaz D, Tyssen D, Hayward J, Gugasyan R, Hearps A, Tachedjian G
Front Cell Infect Microbiol
. 2020 Jan;
9:446.
PMID: 31998660
Non-optimal vaginal microbiota, as observed in bacterial vaginosis (BV), is typically characterized by a depletion of beneficial lactobacilli and an abundance of numerous anaerobes. These non-optimal conditions are associated with...
2.
OReilly L, Putoczki T, Mielke L, Low J, Lin A, Preaudet A, et al.
Immunity
. 2018 Mar;
48(3):570-583.e8.
PMID: 29562203
Polymorphisms in NFKB1 that diminish its expression have been linked to human inflammatory diseases and increased risk for epithelial cancers. The underlying mechanisms are unknown, and the link is perplexing...
3.
Lalaoui N, Hanggi K, Brumatti G, Chau D, Nguyen N, Vasilikos L, et al.
Cancer Cell
. 2016 Sep;
30(3):499-500.
PMID: 27622337
No abstract available.
4.
Brumatti G, Ma C, Lalaoui N, Nguyen N, Navarro M, Tanzer M, et al.
Sci Transl Med
. 2016 May;
8(339):339ra69.
PMID: 27194727
Resistance to chemotherapy is a major problem in cancer treatment, and it is frequently associated with failure of tumor cells to undergo apoptosis. Birinapant, a clinical SMAC mimetic, had been...
5.
Messina N, Fulford T, OReilly L, Loh W, Motyer J, Ellis D, et al.
J Autoimmun
. 2016 Apr;
70:52-62.
PMID: 27068879
The properties of CD4(+) regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show...
6.
de Valle E, Grigoriadis G, OReilly L, Willis S, Maxwell M, Corcoran L, et al.
J Exp Med
. 2016 Mar;
213(4):621-41.
PMID: 27022143
We examined the role of NFκB1 in the homeostasis and function of peripheral follicular (Fo) B cells. Aging mice lacking NFκB1 (Nfκb1(-/-)) develop lymphoproliferative and multiorgan autoimmune disease attributed in...
7.
Lalaoui N, Hanggi K, Brumatti G, Chau D, Nguyen N, Vasilikos L, et al.
Cancer Cell
. 2016 Feb;
29(2):145-58.
PMID: 26859455
Birinapant is a smac-mimetic (SM) in clinical trials for treating cancer. SM antagonize inhibitor of apoptosis (IAP) proteins and simultaneously induce tumor necrosis factor (TNF) secretion to render cancers sensitive...
8.
Aldunate M, Srbinovski D, Hearps A, Latham C, Ramsland P, Gugasyan R, et al.
Front Physiol
. 2015 Jun;
6:164.
PMID: 26082720
Lactic acid and short chain fatty acids (SCFAs) produced by vaginal microbiota have reported antimicrobial and immune modulatory activities indicating their potential as biomarkers of disease and/or disease susceptibility. In...
9.
Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, et al.
Immunol Rev
. 2012 Mar;
246(1):272-85.
PMID: 22435561
Although the diverse functions served by the nuclear factor-κB (NF-κB) pathway in virtually all cell types are typically employed to deal with stress responses, NF-κB transcription factors also play key...
10.
Gugasyan R, Horat E, Kinkel S, Ross F, Grigoriadis G, Gray D, et al.
EMBO J
. 2011 Nov;
31(3):692-706.
PMID: 22124325
The role of specific members of the NF-κB family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-κB1 develop a...