Stephen S G Ferguson
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Explore the profile of Stephen S G Ferguson including associated specialties, affiliations and a list of published articles.
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115
Citations
2746
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Recent Articles
11.
Abd-Elrahman K, Sarasija S, Ferguson S
Curr Neuropharmacol
. 2021 Sep;
21(2):273-283.
PMID: 34530715
Glutamate, the major excitatory neurotransmitter in the brain exerts its effects via both ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs). There are three subgroups of mGluRs, pre-synaptic Group II...
12.
Abd-Elrahman K, Ferguson S
Annu Rev Pharmacol Toxicol
. 2021 Sep;
62:235-254.
PMID: 34516293
Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions responsible for memory and learning. It plays a key role in modulating rapid changes in synaptic transmission and plasticity....
13.
Li S, Colson T, Abd-Elrahman K, Ferguson S
J Pharmacol Exp Ther
. 2021 Jul;
379(1):74-84.
PMID: 34330748
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that leads to progressive motor impairments with no available disease-modifying treatment. Current evidence indicates that exacerbated postsynaptic glutamate signaling in the...
14.
Ibrahim K, McLaren C, Abd-Elrahman K, Ferguson S
Biochem Pharmacol
. 2021 Jan;
185:114427.
PMID: 33513340
Optineurin (OPTN) is a multifunctional protein that mediates a network of cellular processes regulating membrane trafficking, inflammatory responses and autophagy. The OPTN-rich interactome includes Group I metabotropic glutamate receptors (mGluR1...
15.
Abd-Elrahman K, Albaker A, de Souza J, Ribeiro F, Schlossmacher M, Tiberi M, et al.
Sci Signal
. 2020 Dec;
13(662).
PMID: 33323410
The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in both sexes. Aβ-induced activation of...
16.
Ibrahim K, Abd-Elrahman K, El Mestikawy S, Ferguson S
Mol Pharmacol
. 2020 Sep;
98(4):314-327.
PMID: 32873747
Cross talk between both pre- and postsynaptic components of glutamatergic neurotransmission plays a crucial role in orchestrating a multitude of brain functions, including synaptic plasticity and motor planning. Metabotropic glutamate...
17.
de Souza J, Abd-Elrahman K, Ribeiro F, Ferguson S
Mol Brain
. 2020 Aug;
13(1):118.
PMID: 32859226
Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated by the Wnt pathway through β-catenin. Metabotropic glutamate receptor 5 (mGluR5) signaling plays...
18.
Smart K, Nagano-Saito A, Milella M, Sakae D, Favier M, Vigneault E, et al.
J Psychiatry Neurosci
. 2020 Jun;
46(1):E1-E13.
PMID: 32559027
Background: Glutamate transmission is implicated in drug-induced behavioural sensitization and the associated long-lasting increases in mesolimbic output. Metabotropic glutamate type 5 (mGlu5) receptors might be particularly important, but most details...
19.
Abd-Elrahman K, Hamilton A, Albaker A, Ferguson S
ACS Pharmacol Transl Sci
. 2020 Apr;
3(2):334-344.
PMID: 32296772
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is characterized by a progressive cognitive decline in affected individuals. Current therapeutic strategies are limited in their efficacy and some...
20.
Farmer K, Abd-Elrahman K, Derksen A, Rowe E, Thompson A, Rudyk C, et al.
Mol Neurobiol
. 2019 Nov;
57(3):1418-1431.
PMID: 31754998
Parkinson's disease is a neurodegenerative disease characterized by a loss of dopaminergic substantia nigra neurons and depletion of dopamine. To date, current therapeutic approaches focus on managing motor symptoms and...