Stephen P Methot
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Explore the profile of Stephen P Methot including associated specialties, affiliations and a list of published articles.
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17
Citations
439
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Recent Articles
1.
Litzler L, Zahn A, Dionne K, Sprumont A, Ferreira S, Slattery M, et al.
J Exp Med
. 2023 Jun;
220(9).
PMID: 37310381
Positively selected germinal center B cells (GCBC) can either resume proliferation and somatic hypermutation or differentiate. The mechanisms dictating these alternative cell fates are incompletely understood. We show that the...
2.
Padeken J, Methot S, Gasser S
Nat Rev Mol Cell Biol
. 2022 May;
23(9):623-640.
PMID: 35562425
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing....
3.
Delaney C, Methot S, Kalck V, Seebacher J, Hess D, Gasser S, et al.
Nat Struct Mol Biol
. 2022 Apr;
29(5):502.
PMID: 35428846
No abstract available.
4.
Delaney C, Methot S, Kalck V, Seebacher J, Hess D, Gasser S, et al.
Nat Struct Mol Biol
. 2022 Feb;
29(2):85-96.
PMID: 35102319
Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show that in addition to ensuring H3K9me,...
5.
Methot S, Padeken J, Brancati G, Zeller P, Delaney C, Gaidatzis D, et al.
Nat Cell Biol
. 2021 Nov;
23(11):1163-1175.
PMID: 34737442
The developmental role of histone H3K9 methylation (H3K9me), which typifies heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a highly divergent upregulation of genes with tissue and...
6.
Morande P, Yan X, Sepulveda J, Seija N, Marquez M, Sotelo N, et al.
Blood
. 2021 Jul;
138(3):246-258.
PMID: 34292322
Most cancers become more dangerous by the outgrowth of malignant subclones with additional DNA mutations that favor proliferation or survival. Using chronic lymphocytic leukemia (CLL), a disease that exemplifies this...
7.
Padeken J, Zeller P, Towbin B, Katic I, Kalck V, Methot S, et al.
Genes Dev
. 2019 Feb;
33(7-8):436-451.
PMID: 30804228
has two histone H3 Lys9 methyltransferases, MET-2 (SETDB1 homolog) and SET-25 (G9a/SUV39H1 related). In worms, we found simple repeat sequences primarily marked by H3K9me2, while transposable elements and silent tissue-specific...
8.
Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65
Delaney C, Methot S, Guidi M, Katic I, Gasser S, Padeken J
J Cell Biol
. 2019 Feb;
218(3):820-838.
PMID: 30737265
The segregation of the genome into accessible euchromatin and histone H3K9-methylated heterochromatin helps silence repetitive elements and tissue-specific genes. In , MET-2, the homologue of mammalian SETDB1, catalyzes H3K9me1 and...
9.
Litzler L, Zahn A, Meli A, Hebert S, Patenaude A, Methot S, et al.
Nat Commun
. 2019 Jan;
10(1):22.
PMID: 30604754
Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine...
10.
Methot S, Litzler L, Subramani P, Eranki A, Fifield H, Patenaude A, et al.
Nat Commun
. 2018 Mar;
9(1):1248.
PMID: 29593215
Activation-induced deaminase (AID) mutates the immunoglobulin (Ig) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B cells, thus underpinning antibody responses. AID mutates a few hundred...