Stephen P Mackessy
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Explore the profile of Stephen P Mackessy including associated specialties, affiliations and a list of published articles.
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100
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1597
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Recent Articles
1.
Bernstein J, Francioli Y, Schield D, Adams R, Perry B, Farleigh K, et al.
Mol Phylogenet Evol
. 2025 Feb;
206:108309.
PMID: 39938672
Species tree inference is often assumed to be more accurate as datasets increase in size, with whole genomes representing the best-case-scenario for estimating a single, most-likely speciation history with high...
2.
Balchan N, Crowther T, Kratz G, Mackessy S
Toxicon
. 2025 Feb;
256:108275.
PMID: 39914593
Snake venoms are complex biochemical secretions under strong selection for prey subjugation, and venoms are tightly linked to the biotic communities that snakes inhabit. Physiological adaptations for venom resistance have...
3.
Vazquez Torres S, Benard Valle M, Mackessy S, Menzies S, Casewell N, Ahmadi S, et al.
Nature
. 2025 Jan;
639(8053):225-231.
PMID: 39814879
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic...
4.
Meik J, Watson J, Schield D, Perry B, Francioli Y, Guss H, et al.
R Soc Open Sci
. 2024 Aug;
11(8):240345.
PMID: 39113769
Both the metabolic theory of ecology and dynamic energy budget theory predict that climate influences body size through its effects on first-order determinants of energetics: reactive temperatures, carbon resources and...
5.
Vazquez Torres S, Benard Valle M, Mackessy S, Menzies S, Casewell N, Ahmadi S, et al.
Res Sq
. 2024 May;
PMID: 38798548
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic...
6.
Gopalan S, Perry B, Francioli Y, Schield D, Guss H, Bernstein J, et al.
Genome Biol Evol
. 2024 May;
16(7).
PMID: 38753011
Understanding and predicting the relationships between genotype and phenotype is often challenging, largely due to the complex nature of eukaryotic gene regulation. A step towards this goal is to map...
7.
Smith C, Brandehoff N, Pepin L, McCabe M, Castoe T, Mackessy S, et al.
Anal Sci Adv
. 2024 May;
4(1-2):26-36.
PMID: 38715579
Biofluid proteomics is a sensitive and high throughput technique that provides vast amounts of molecular data for biomarker discovery. More recently, dried blood spots (DBS) have gained traction as a...
8.
Smith C, Modahl C, Galindo D, Larson K, Maroney S, Bahrabadi L, et al.
Mol Cell Proteomics
. 2024 Apr;
23(6):100779.
PMID: 38679388
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of...
9.
Modahl C, Han S, van Thiel J, Vaz C, Dunstan N, Frietze S, et al.
BMC Genomics
. 2024 Feb;
25(1):186.
PMID: 38365592
Background: Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions...
10.
Balchan N, Smith C, Mackessy S
Toxicon X
. 2023 Dec;
21:100179.
PMID: 38144228
Predation has the potential to impart strong selective pressures on organisms within their environments, resulting in adaptive changes in prey that minimize risk of predation. Pressures from venomous snakes present...