Stephen L Hart
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Explore the profile of Stephen L Hart including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Hart S, Harrison P
Curr Opin Pharmacol
. 2017 Nov;
34:119-124.
PMID: 29107808
Gene therapy for cystic fibrosis (CF) has been the subject of intense research over the last twenty-five years or more, using both viral and liposomal delivery methods, but so far...
22.
Yu-Wai-Man C, Tagalakis A, Meng J, Bouremel Y, Lee R, Virasami A, et al.
JAMA Ophthalmol
. 2017 Oct;
135(11):1147-1155.
PMID: 28975281
Importance: Postsurgical fibrosis is a critical determinant of the long-term success of glaucoma surgery, but no reliable biomarkers are currently available to stratify the risk of scarring. Objective: To compare...
23.
Yu-Wai-Man C, Owen N, Lees J, Tagalakis A, Hart S, Webster A, et al.
Sci Rep
. 2017 Jul;
7(1):5644.
PMID: 28717200
Fibrosis-related events play a part in most blinding diseases worldwide. However, little is known about the mechanisms driving this complex multifactorial disease. Here we have carried out the first genome-wide...
24.
Manunta M, Tagalakis A, Attwood M, Aldossary A, Barnes J, Munye M, et al.
Sci Rep
. 2017 Apr;
7(1):700.
PMID: 28386087
The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been...
25.
Munye M, Shoemark A, Hirst R, Delhove J, Sharp T, McKay T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Dec;
312(2):L258-L267.
PMID: 27979861
Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway, but their proliferative potential is limited. To extend proliferation,...
26.
Munye M, Tagalakis A, Barnes J, Brown R, McAnulty R, Howe S, et al.
Sci Rep
. 2016 Mar;
6:23125.
PMID: 26975732
Gene therapy for cystic fibrosis using non-viral, plasmid-based formulations has been the subject of intensive research for over two decades but a clinically viable product has yet to materialise in...
27.
Yu-Wai-Man C, Tagalakis A, Manunta M, Hart S, Khaw P
Sci Rep
. 2016 Feb;
6:21881.
PMID: 26905457
There is increasing evidence that the Myocardin-related transcription factor/Serum response factor (MRTF/SRF) pathway plays a key role in fibroblast activation and that knocking down MRTF can lead to reduced scarring...
28.
Kwok A, McCarthy D, Hart S, Tagalakis A
Chem Biol Drug Des
. 2015 Dec;
87(5):747-63.
PMID: 26684657
The effects of lysine peptide lengths on DNA and siRNA packaging and delivery were studied using four linear oligolysine peptides with 8 (K8), 16 (K16), 24 (K24) and 32 (K32)...
29.
Tagalakis A, Castellaro S, Zhou H, Bienemann A, Munye M, McCarthy D, et al.
Int J Nanomedicine
. 2015 Apr;
10:2673-83.
PMID: 25878500
Nonviral gene and small interfering RNA (siRNA) delivery formulations are extensively used for biological and therapeutic research in cell culture experiments, but less so in in vivo and clinical research....
30.
Munye M, Ravi J, Tagalakis A, McCarthy D, Ryadnov M, Hart S
Sci Rep
. 2015 Mar;
5:9292.
PMID: 25786833
Lipopolyplexes are of widespread interest for gene therapy due to their multifunctionality and high transfection efficiencies. Here we compared the biological and biophysical properties of a lipopolyplex formulation with its...