Stephen L Hart
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Explore the profile of Stephen L Hart including associated specialties, affiliations and a list of published articles.
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74
Citations
988
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Recent Articles
11.
Irving E, Tagalakis A, Maeshima R, Hart S, Eaton S, Lehtonen A, et al.
Sci Rep
. 2020 Oct;
10(1):16660.
PMID: 33028860
Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted...
12.
Maeshima R, Moulding D, Stoker A, Hart S
Nucleic Acid Ther
. 2020 Apr;
30(4):237-248.
PMID: 32240058
Neuroblastoma (NB) is the most common solid tumor in childhood. Twenty percent of patients display amplification, which indicates a very poor prognosis. is a highly specific target for an NB...
13.
Meng J, Tagalakis A, Hart S
Sci Rep
. 2020 Jan;
10(1):1046.
PMID: 31974512
P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours. The...
14.
Boyd A, Guo S, Huang L, Kerem B, Oren Y, Walker A, et al.
J Cyst Fibros
. 2020 Jan;
19 Suppl 1:S54-S59.
PMID: 31948871
Gene therapy offers great promise for cystic fibrosis which has never been quite fulfilled due to the challenges of delivering sufficient amounts of the CFTR gene and expression persistence for...
15.
Bilip M, Shah S, Mathiyalakan M, Tagalakis A, Hart S, Maeshima R, et al.
J Drug Target
. 2020 Jan;
28(6):643-654.
PMID: 31903789
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells. However, although therapeutically effective, retinoids have only...
16.
Lee M, Wang H, White T, Brooks T, Pittman A, Halai H, et al.
J Invest Dermatol
. 2019 Nov;
140(5):1035-1044.e7.
PMID: 31705875
Keratitis-ichthyosis-deafness (KID) syndrome is a severe, untreatable condition characterized by ocular, auditory, and cutaneous abnormalities, with major complications of infection and skin cancer. Most cases of KID syndrome (86%) are...
17.
Ivanova R, Benton D, Munye M, Rangseesorranan S, Hart S, Moss G
ACS Appl Mater Interfaces
. 2019 Jan;
11(9):8731-8739.
PMID: 30648848
Ciliated lung epithelial cells and the airway surface liquid (ASL) comprise one of the body's most important protective systems. This system is finely tuned, and perturbations to ASL rheology, ASL...
18.
Mohammadi A, Kudsiova L, Mohd Mustapa M, Campbell F, Vlaho D, Welser K, et al.
Org Biomol Chem
. 2019 Jan;
17(4):945-957.
PMID: 30629080
The formation of a novel trichain (TC) lipid was discovered when a cationic lipid possessing a terminal hydroxyl group and the helper lipid dioleoyl l-α-phosphatidylethanolamine (DOPE) were formulated as vesicles...
19.
Fernando O, Tagalakis A, Awwad S, Brocchini S, Khaw P, Hart S, et al.
Mol Ther
. 2018 Oct;
26(12):2812-2822.
PMID: 30301666
RNAi induced by double-stranded small interfering RNA (siRNA) molecules has attracted great attention as a naturally occurring approach to silence gene expression with high specificity. The myocardin-related transcription factor/serum response...
20.
Tagalakis A, Munye M, Ivanova R, Chen H, Smith C, Aldossary A, et al.
Thorax
. 2018 May;
73(9):847-856.
PMID: 29748250
Introduction: Loss of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to upregulation of the epithelial sodium...