Stephen L Dewey
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Explore the profile of Stephen L Dewey including associated specialties, affiliations and a list of published articles.
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47
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788
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Recent Articles
1.
Mader S, Brimberg L, Vo A, Strohl J, Crawford J, Bonnin A, et al.
Sci Transl Med
. 2022 Apr;
14(641):eabe9726.
PMID: 35442708
The fetal brain is constantly exposed to maternal IgG before the formation of an effective blood-brain barrier (BBB). Here, we studied the consequences of fetal brain exposure to an antibody...
2.
Juncosa J, Takaya K, Le H, Moschitto M, Weerawarna P, Mascarenhas R, et al.
J Am Chem Soc
. 2018 Jan;
140(6):2151-2164.
PMID: 29381352
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as...
3.
Lerner R, Francardo V, Fujita K, Bimpisidis Z, Jourdain V, Tang C, et al.
Sci Rep
. 2017 Nov;
7(1):16005.
PMID: 29167476
Chronic levodopa treatment leads to the appearance of dyskinesia in the majority of Parkinson's disease patients. Neurovascular dysregulation in putaminal and pallidal regions is thought to be an underlying feature...
4.
Santoro G, Carrion J, Dewey S
J Alcohol Drug Depend
. 2017 Oct;
5(2).
PMID: 29046888
The rate of opioid overdose continues to rise, necessitating improved treatment options. Current therapeutic approaches rely on administration of either a blocking agent, such as naloxone, or chronic treatment with...
5.
Santoro G, Carrion J, Patel K, Vilchez C, Veith J, Brodie J, et al.
Neuropsychopharmacology
. 2017 Apr;
42(9):1841-1849.
PMID: 28393895
Methadone and buprenorphine are currently the most common pharmacological treatments for opioid dependence. Interestingly, the clinical response to these drugs appears to be sex specific. That is, females exhibit superior...
6.
Prabhakaran J, Dewey S, McClure R, Simpson N, Tantawy M, Mann J, et al.
Bioorg Med Chem Lett
. 2017 Jan;
27(4):941-943.
PMID: 28094184
In vivo evaluation of [F]BMS-754807 binding in mice and rats using microPET and biodistribution methods is described herein. The radioligand shows consistent binding characteristics, in vivo, in both species. Early...
7.
Santoro G, Shukla S, Patel K, Kaczmarzyk J, Agorastos S, Scherrer S, et al.
J Addict Res Ther
. 2017 Jan;
7(4).
PMID: 28078167
The rate of Neonatal Abstinence Syndrome (NAS) has drastically increased over the past decade. The average hospital expense per NAS patient has tripled, while the number of babies born to...
8.
Lerner R, Bimpisidis Z, Agorastos S, Scherrer S, Dewey S, Cenci M, et al.
Neurobiol Dis
. 2016 Aug;
96:31-37.
PMID: 27544483
Dissociation of vasomotor and metabolic responses to levodopa has been observed in human subjects with Parkinson's disease (PD) studied with PET and in autoradiograms from 6-hydroxydopamine (6-OHDA) rat. In both...
9.
Vo A, Sako W, Dewey S, Eidelberg D, Ulug A
Neurobiol Dis
. 2014 Dec;
73:399-406.
PMID: 25447231
TorsinA is an important protein in brain development, and plays a role in the regulation of neurite outgrowth and synaptic function. Patients with the most common form of genetic dystonia...
10.
Vo A, Volpe B, Tang C, Schiffer W, Kowal C, Huerta P, et al.
J Cereb Blood Flow Metab
. 2014 May;
34(8):1315-20.
PMID: 24824914
Systemic lupus erythematosus (SLE) is characterized by multiorgan inflammation, neuropsychiatric disorders (NPSLE), and anti-nuclear antibodies. We previously identified a subset of anti-DNA antibodies (DNRAb) cross-reactive with the N-methyl-D-aspartate receptor, present...