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Stephen J Lippard

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Articles 374
Citations 11988
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Recent Articles
11.
Ling X, Chen X, Riddell I, Tao W, Wang J, Hollett G, et al.
Nano Lett . 2018 Jun; 18(7):4618-4625. PMID: 29902013
Despite the broad antitumor spectrum of cisplatin, its therapeutic efficacy in cancer treatment is compromised by the development of drug resistance in tumor cells and systemic side effects. A close...
12.
Hucke A, Park G, Bauer O, Beyer G, Koppen C, Zeeh D, et al.
Front Chem . 2018 Jun; 6:180. PMID: 29888219
Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug...
13.
He C, DuBois J, Hedman B, Hodgson K, Lippard S
Angew Chem Int Ed Engl . 2018 May; 40(8):1484-1487. PMID: 29712360
A copper-copper separation of about 2.84 Å is determined by extended X-ray absorption fine structure studies for the (μ-1,2-peroxo)dicopper(II) species 1, which has only a 1,8-naphthyridine unit as an additional...
14.
Merkx M, Kopp D, Sazinsky M, Blazyk J, Muller J, Lippard S
Angew Chem Int Ed Engl . 2018 May; 40(15):2782-2807. PMID: 29711993
Methanotrophic bacteria are capable of using methane as their sole source of carbon and energy. The first step in methane metabolism, the oxidation of methane to methanol, is catalyzed by...
15.
Vernekar A, Berger G, Czapar A, Veliz F, Wang D, Steinmetz N, et al.
J Am Chem Soc . 2018 Mar; 140(12):4279-4287. PMID: 29553267
Efficient loading of drugs in novel delivery agents has the potential to substantially improve therapy by targeting the diseased tissue while avoiding unwanted side effects. Here we report the first...
16.
Goldberg J, Lippard S
Biochemistry . 2018 Mar; 57(27):3991-3992. PMID: 29553247
No abstract available.
17.
Zhou W, Almeqdadi M, Xifaras M, Riddell I, Yilmaz O, Lippard S
Chem Commun (Camb) . 2018 Feb; 54(22):2788-2791. PMID: 29484327
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer...
18.
Goldberg J, Wang F, Sessler C, Vogler N, Zhang D, Loucks W, et al.
J Am Chem Soc . 2018 Feb; 140(6):2020-2023. PMID: 29384658
Fluorescent sensors for mobile zinc are valuable for studying complex biological systems. Because these sensors typically bind zinc rapidly and tightly, there has been little temporal control over the activity...
19.
Richardson C, Cunden L, Butty V, Nolan E, Lippard S, Shoulders M
J Am Chem Soc . 2018 Jan; 140(7):2413-2416. PMID: 29334734
We describe the preparation, evaluation, and application of an S100A12 protein-conjugated solid support, hereafter the "A12-resin", that can remove 99% of Zn(II) from complex biological solutions without significantly perturbing the...
20.
Berger G, Grauwet K, Zhang H, Hussey A, Nowicki M, Wang D, et al.
Cancer Lett . 2017 Dec; 416:138-148. PMID: 29246647
Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor with a median patient survival of less than two years, even with the optimal standard of care, namely, surgical...