Stephen J Benkovic
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Explore the profile of Stephen J Benkovic including associated specialties, affiliations and a list of published articles.
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184
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Recent Articles
1.
He J, Zou L, Pareek V, Benkovic S
bioRxiv
. 2025 Feb;
PMID: 39975334
We describe peptide mapping through lit ntibiotic esistance omplementation (SpARC-map), a method to identify the probable interface between two interacting proteins. Our method is based on in vivo affinity selection...
2.
Tang J, Weiser N, Wang G, Chowdhry S, Curtis E, Zhao Y, et al.
Nature
. 2024 Nov;
635(8037):210-218.
PMID: 39506153
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival. At...
3.
Sha Z, Benkovic S
J Biol Chem
. 2024 Aug;
300(9):107620.
PMID: 39098527
In this study, we advance our understanding of the spatial relationship between the purinosome, a liquid condensate consisting of six enzymes involved in de novo purine biosynthesis, and mitochondria. Previous...
4.
Feng X, Spiering M, de Luna Almeida Santos R, Benkovic S, Li H
Nat Commun
. 2023 Jul;
14(1):4396.
PMID: 37474605
The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how...
5.
Feng X, Spiering M, de Luna Almeida Santos R, Benkovic S, Li H
bioRxiv
. 2023 May;
PMID: 37205424
The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome complex to couple DNA unwinding with RNA primer synthesis for DNA replication. How a primosome is assembled and...
6.
Ma Q, Yang Q, Xu J, Sellers H, Brown Z, Liu Z, et al.
Eur Heart J
. 2023 Feb;
44(14):1265-1279.
PMID: 36721994
Aims: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of pulmonary hypertension (PH). Proliferative cells utilize purine bases from the de novo purine synthesis (DNPS) pathways for nucleotide...
7.
Ma Q, Yang Q, Xu J, Zhang X, Kim D, Liu Z, et al.
Circulation
. 2022 Sep;
146(19):1444-1460.
PMID: 36073366
Background: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of arterial diseases, especially in arterial restenosis after angioplasty or stent placement. VSMCs reprogram their metabolism to meet the...
8.
He J, Zou L, Pareek V, Benkovic S
J Biol Chem
. 2022 Mar;
298(5):101853.
PMID: 35331738
There is growing evidence that mammalian cells deploy a mitochondria-associated metabolon called the purinosome to perform channeled de novo purine biosynthesis (DNPB). However, the molecular mechanisms of this substrate-channeling pathway...
9.
Pedley A, Pareek V, Benkovic S
Annu Rev Biochem
. 2022 Mar;
91:89-106.
PMID: 35320684
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de...
10.
Pedley A, Boylan J, Chan C, Kennedy E, Kyoung M, Benkovic S
J Biol Chem
. 2022 Mar;
298(5):101845.
PMID: 35307352
Enzymes within the de novo purine biosynthetic pathway spatially organize into dynamic intracellular assemblies called purinosomes. The formation of purinosomes has been correlated with growth conditions resulting in high purine...