Ali Tavassoli
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Explore the profile of Ali Tavassoli including associated specialties, affiliations and a list of published articles.
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66
Citations
1093
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Recent Articles
1.
Ismail M, Martin S, George R, Houghton F, Kelly G, Chaleil R, et al.
Sci Rep
. 2025 Mar;
15(1):8756.
PMID: 40082628
No abstract available.
2.
McDermott A, Tavassoli A
Transcription
. 2024 Oct;
:1-32.
PMID: 39470609
Hypoxia-inducible factors (HIFs) play a pivotal role as master regulators of tumor survival and growth, controlling a wide array of cellular processes in response to hypoxic stress. Clinical data correlates...
3.
McDermott A, Windeln L, Valentine J, Baldassarre L, Foster A, Tavassoli A
ACS Chem Biol
. 2024 Sep;
19(10):2232-2239.
PMID: 39312747
Split-intein circular ligation of proteins and peptides (SICLOPPS) is a method for generating intracellular libraries of cyclic peptides that has yielded several first-in-class inhibitors. Here, we detail a revised high-content,...
4.
Ball A, Mohammed S, Doigneaux C, Gardner R, Easton J, Turner S, et al.
J Am Chem Soc
. 2024 Mar;
146(13):8877-8886.
PMID: 38503564
Hypoxia inducible factor (HIF) is a heterodimeric transcription factor composed of an oxygen-regulated α subunit and a constitutively expressed β subunit that serves as the master regulator of the cellular...
5.
Saady A, Malcolm G, Fitzpatrick M, Pairault N, Tizzard G, Mohammed S, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(16):e202400344.
PMID: 38276911
Inspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is "switched on" by breaking the mechanical bond have been reported. However,...
6.
Sohrabi C, Foster A, Tavassoli A
Nat Rev Chem
. 2023 May;
4(2):90-101.
PMID: 37128052
Drug discovery has traditionally focused on using libraries of small molecules to identify therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic peptides, are increasingly used for this...
7.
Zhao J, Zhou X, Chen B, Lu M, Wang G, Elumalai N, et al.
Cell Death Dis
. 2023 Feb;
14(2):87.
PMID: 36750554
The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous...
8.
Ismail M, Martin S, George R, Houghton F, Kelly G, Chaleil R, et al.
Sci Rep
. 2023 Feb;
13(1):1889.
PMID: 36732563
P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly with its RAS...
9.
Taghizadeh Armaki M, Jafarzadeh J, Mahdavi Omran S, Bayani M, Tavassoli A, Faeli L, et al.
Curr Med Mycol
. 2023 Jan;
8(2):49-54.
PMID: 36654791
Background And Purpose: Invasive mucormycosis is a rare mycosis that affects most cases of uncontrolled diabetes and has a high mortality rate. Patients with COVID-19 are at high risk of...
10.
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Brereton C, Yao L, Davies E, Zhou Y, Vukmirovic M, Bell J, et al.
Elife
. 2022 Feb;
11.
PMID: 35188460
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function...