Stephen Hanessian
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Explore the profile of Stephen Hanessian including associated specialties, affiliations and a list of published articles.
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156
Citations
1004
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Recent Articles
1.
Vaillancourt M, Mishra A, Duchamp E, Hanessian S
J Org Chem
. 2024 Oct;
89(20):15170-15186.
PMID: 39358033
Methods have been developed for the stereocontrolled synthesis of bicyclic diaza [3.3.0] octane carboxylic acids as possible isosteres of piperazine 2-carboxylic acid. In the first approach, l-pyroglutamic acid was functionalized...
2.
Duchamp E, Vasquez G, Firoozi N, Freestone G, Oestergaard M, Seth P, et al.
RSC Adv
. 2024 Jul;
14(33):23583-23591.
PMID: 39070250
Therapeutic oligonucleotides are chemically modified to enhance their drug-like properties - including binding affinity for target RNA. Many nucleic acid analogs that enhance RNA binding affinity constrain the furanose sugar...
3.
Garsi J, Hocine S, Hensienne R, Moitessier M, Denton H, Major L, et al.
Bioorg Med Chem Lett
. 2024 Jul;
110:129883.
PMID: 39013490
The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for continued propagation of neglected tropical diseases such as African sleeping sickness, Chagas disease and leishmaniasis respectively. Following...
4.
Hanessian S
J Org Chem
. 2024 Jun;
89(13):9147-9186.
PMID: 38865159
A retrospective is presented highlighting the synthesis of selected "first-in-kind" natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with...
5.
Garsi J, Aguiar P, Berger G, Maris T, Hanessian S
J Org Chem
. 2024 Mar;
89(7):4283-4293.
PMID: 38489026
The synthesis and conformational properties of oligo-proline mimetics composed of dimeric and tetrameric Pro-Cyp constructs linked by a hydroxymethylene unit are reported. Oligomers were studied both in the solid state...
6.
Hocine S, Duchamp E, Mishra A, Fourquez J, Hanessian S
J Org Chem
. 2023 Mar;
88(7):4675-4686.
PMID: 36940388
We report the synthesis of two novel azaperhydroazulene tropane-hederacine chimeras and , which contain an 8-azabicyclo[3.2.1]octane ring and a 7-azabicyclo[4.1.1]octane ring, respectively. The synthesis of both chimeras was achieved by...
7.
Rajasekaran T, Freestone G, Galindo-Murillo R, Lugato B, Gaus H, Migawa M, et al.
J Org Chem
. 2023 Mar;
88(6):3599-3614.
PMID: 36857642
We recently described a chemical strategy to pre-organize a trinucleotide subunit in a conformation suitable for Watson-Crick base pairing for modulating the binding kinetics of single-stranded oligonucleotides (ONs) using bis-phosphonate...
8.
Finicle B, Eckenstein K, Revenko A, Anderson B, Wan W, McCracken A, et al.
Nucleic Acids Res
. 2023 Feb;
51(4):1583-1599.
PMID: 36727438
Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but...
9.
Duchamp E, Devin R, Aguiar P, Gaucherand A, Hanessian S
J Org Chem
. 2022 Nov;
87(22):15713-15718.
PMID: 36349937
Polygonapholine was isolated in 1997 from the rhizome. Based on spectroscopic data, it was assigned a structure comprising an unusual -2,6-disubstituted -aryl morpholine ring to which is attached a ()-4-hydroxycinnamate...
10.
Kiyeleko S, Hocine S, Mautino G, Kuenemann M, Nawrotek A, Miallau L, et al.
Bioorg Med Chem Lett
. 2022 Aug;
75:128950.
PMID: 36030002
We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD). Appending...