Amit Kumar Chattopadhyay
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Explore the profile of Amit Kumar Chattopadhyay including associated specialties, affiliations and a list of published articles.
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12
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65
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Recent Articles
1.
Wurtz N, Shirude P, Cheney D, Lupisella J, Chattopadhyay A, Baligar V, et al.
ACS Med Chem Lett
. 2024 Sep;
15(9):1500-1505.
PMID: 39291022
We report the discovery and optimization of aryl piperidinone urea formyl peptide receptor 2 (FPR2) agonists from a weakly active high-throughput screening (HTS) hit to potent and selective agonists with...
2.
Chattopadhyay A, Hanessian S
Chem Rev
. 2017 Feb;
117(5):4104-4146.
PMID: 28205435
Daphniphyllum is an evergreen species known since 1826. After initial systematic investigations, more than 320 members of this family have been isolated, which comprise complex and fascinating structures. Unique azapolycyclic...
3.
Chattopadhyay A, Berger G, Hanessian S
J Org Chem
. 2016 Jun;
81(12):5074-86.
PMID: 27251014
Herein we describe synthetic efforts toward the total synthesis of calyciphylline B-type alkaloids. In the process, we disclose a detailed DFT study of equilibrium geometries and transition states that explains...
4.
Chattopadhyay A, Menz H, Ly V, Dorich S, Hanessian S
J Org Chem
. 2016 Feb;
81(5):2182-8.
PMID: 26878089
Herein, we report the enantioselective synthesis of a functionalized aza-octahydropentalene and its elaboration to a model tetracyclic core structure of calyciphylline B-type alkaloids.
5.
Chattopadhyay A, Ly V, Jakkepally S, Berger G, Hanessian S
Angew Chem Int Ed Engl
. 2016 Jan;
55(7):2577-81.
PMID: 26765928
Herein we describe the first synthetic efforts toward the total synthesis of isodaphlongamine H, a calyciphylline B-type alkaloid. The strategy employs a chemoenzymatic process for the preparation of a functionalized...
6.
Chattopadhyay A, Hanessian S
Chem Commun (Camb)
. 2015 Oct;
51(92):16450-67.
PMID: 26490499
Among many other strategies, the enaminone approach is an important strategy to construct and diversify the azacyclic core in various alkaloids syntheses. In this brief review we discuss the application...
7.
Chattopadhyay A, Hanessian S
Chem Commun (Camb)
. 2015 Oct;
51(92):16437-49.
PMID: 26490402
Cyclic enaminones are versatile intermediates to construct a variety of azacyclic frameworks and have been widely used in alkaloid synthesis. Here, we summarize three approaches for stereoselective syntheses of cyclic...
8.
Hanessian S, Chattopadhyay A
Org Lett
. 2013 Dec;
16(1):232-5.
PMID: 24341416
A one-pot, mild, two-component iminium ion-enamine cascade reaction to construct structurally diverse azacyclic frameworks from l-proline and l-pipecolic acid, and its application to indolizidine and quinolizidine alkaloids and azasteroids, is...
9.
Hanessian S, Dorich S, Chattopadhyay A, Buschleb M
J Org Chem
. 2013 Aug;
78(17):8915-21.
PMID: 23915281
Although the [2,3]-Wittig and Wittig-Still rearrangements have long been known, their application in the generation of quaternary carbon centers in carbocyclic ring systems is sparse. Model studies utilizing this strategy...
10.
Tourigny D, Fernandez I, Kelley A, Vakiti R, Chattopadhyay A, Dorich S, et al.
J Mol Biol
. 2013 May;
425(20):3907-10.
PMID: 23702293
Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as potential antiprotozoal and antitumor drugs. Here, we report a 3.1-Å crystal structure of...