Stephen H Wright
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Explore the profile of Stephen H Wright including associated specialties, affiliations and a list of published articles.
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75
Citations
2163
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Recent Articles
1.
Farrera D, Alaaldin M, Lindberg P, Sample P, Lenzen-Hammerel P, LaMadrid C, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100043.
PMID: 40054126
Valsartan (VAL) is commonly prescribed for patients with cardiovascular disease (CVD) to lower blood pressure, reduce heart failure risk, and prevent heart attacks or strokes by blocking the effects of...
2.
Martinez-Guerrero L, Zhang X, Wright S, Cherrington N
J Pharmacol Exp Ther
. 2024 Apr;
391(3):378-386.
PMID: 38627096
Organic anions (OAs) are compounds including drugs or toxicants that are negatively charged at physiologic pH and are typically transported by organic anion transporters (OATs). Human OAT4 (SLC22A11) is expressed...
3.
Hau R, Wright S, Cherrington N
Clin Pharmacol Ther
. 2023 Jul;
114(4):780-794.
PMID: 37404197
The US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceuticals and Medical Devices Agency (PMDA) guidances on small-molecule drug-drug interactions (DDIs), with input from the International Transporter...
4.
Hau R, Wright S, Cherrington N
Drug Metab Dispos
. 2023 May;
51(9):1157-1168.
PMID: 37258305
The blood-testis barrier (BTB) is a selectively permeable membrane barrier formed by adjacent Sertoli cells (SCs) in the seminiferous tubules of the testes that develops intercellular junctional complexes to protect...
5.
Representative Rodent Models for Renal Transporter Alterations in Human Nonalcoholic Steatohepatitis
Frost K, Jilek J, Toth E, Goedken M, Wright S, Cherrington N
Drug Metab Dispos
. 2023 May;
51(8):970-981.
PMID: 37137719
Alterations in renal elimination processes of glomerular filtration and active tubular secretion by renal transporters can result in adverse drug reactions. Nonalcoholic steatohepatitis (NASH) alters hepatic transporter expression and xenobiotic...
6.
Vignaux P, Lane T, Puhl A, Hau R, Wright S, Cherrington N, et al.
ACS Omega
. 2023 Apr;
8(13):12532-12537.
PMID: 37033868
Pyronaridine, tilorone and quinacrine are cationic molecules that have activity against Ebola, SARS-CoV-2 and other viruses. All three molecules have also demonstrated activity against Ebola in mice, while pyronaridine showed...
7.
Marie S, Frost K, Hau R, Martinez-Guerrero L, Izu J, Myers C, et al.
Acta Pharm Sin B
. 2023 Feb;
13(1):1-28.
PMID: 36815037
The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific alterations to the absorption, distribution, metabolism, and excretion...
8.
Hau R, Wright S, Cherrington N
Drug Metab Dispos
. 2023 Feb;
51(5):560-571.
PMID: 36732077
Transporters are involved in the movement of many physiologically important molecules across cell membranes and have a substantial impact on the pharmacological and toxicological effect of xenobiotics. Many transporters have...
9.
Frost K, Jilek J, Sinari S, Klein R, Billheimer D, Wright S, et al.
Drug Metab Dispos
. 2022 Nov;
51(2):155-164.
PMID: 36328481
Alterations in hepatic transporters have been identified in precirrhotic chronic liver diseases (CLDs) that result in pharmacokinetic variations causing adverse drug reactions (ADRs). However, the effect of CLD on the...
10.
Lane T, Urbina F, Zhang X, Fye M, Gerlach J, Wright S, et al.
Mol Pharm
. 2022 Oct;
19(11):4320-4332.
PMID: 36269563
The uptake transporter OATP1B1 (SLC01B1) is largely localized to the sinusoidal membrane of hepatocytes and is a known victim of unwanted drug-drug interactions. Computational models are useful for identifying potential...