Stephen G Landt
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Explore the profile of Stephen G Landt including associated specialties, affiliations and a list of published articles.
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11
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2429
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Recent Articles
1.
Nakamura R, Landt S, Mai E, Nejim J, Chen L, Frankel A
PLoS One
. 2012 Nov;
7(10):e48194.
PMID: 23133567
We have developed a mammalian cell-based screening platform to identify proteins that assemble into RNA-protein complexes. Based on Tat-mediated activation of the HIV LTR, proteins that interact with an RNA...
2.
Landt S, Marinov G, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, et al.
Genome Res
. 2012 Sep;
22(9):1813-31.
PMID: 22955991
Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq) has become a valuable and widely used approach for mapping the genomic location of transcription-factor binding and histone modifications in living...
3.
Gerstein M, Kundaje A, Hariharan M, Landt S, Yan K, Cheng C, et al.
Nature
. 2012 Sep;
489(7414):91-100.
PMID: 22955619
Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes; the ensemble of these binding events forms a regulatory network, constituting the wiring diagram for a...
4.
Stamatoyannopoulos J, Snyder M, Hardison R, Ren B, Gingeras T, Gilbert D, et al.
Genome Biol
. 2012 Aug;
13(8):418.
PMID: 22889292
To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the same experimental pipelines...
5.
Landt S, Abeliuk E
Methods Mol Biol
. 2012 Jun;
905:29-39.
PMID: 22735996
Whole-genome tiling arrays are powerful tools for detecting and characterizing novel RNA transcripts. Here, we describe a complete method combining elements of molecular and computational biology to identify small noncoding...
6.
Maston G, Landt S, Snyder M, Green M
Annu Rev Genomics Hum Genet
. 2012 Jun;
13:29-57.
PMID: 22703170
There has been a recent surge in the use of genome-wide methodologies to identify and annotate the transcriptional regulatory elements in the human genome. Here we review some of these...
7.
Karczewski K, Tatonetti N, Landt S, Yang X, Slifer T, Altman R, et al.
Proc Natl Acad Sci U S A
. 2011 Aug;
108(32):13353-8.
PMID: 21828005
Regulation of gene expression at the transcriptional level is achieved by complex interactions of transcription factors operating at their target genes. Dissecting the specific combination of factors that bind each...
8.
Landt S, Lesley J, Britos L, Shapiro L
J Bacteriol
. 2010 Jul;
192(18):4763-75.
PMID: 20601471
Small noncoding regulatory RNAs (sRNAs) play a key role in the posttranscriptional regulation of many bacterial genes. The genome of Caulobacter crescentus encodes at least 31 sRNAs, and 27 of...
9.
Landt S, Abeliuk E, McGrath P, Lesley J, McAdams H, Shapiro L
Mol Microbiol
. 2008 Apr;
68(3):600-14.
PMID: 18373523
Small non-coding RNAs (sRNAs) are active in many bacterial cell functions, including regulation of the cell's response to environmental challenges. We describe the identification of 27 novel Caulobacter crescentus sRNAs...
10.
Landt S, Ramirez A, Daugherty M, Frankel A
J Mol Biol
. 2005 Aug;
351(5):982-94.
PMID: 16055152
DNA in a single-stranded form (ssDNA) exists transiently within the cell and comprises the telomeres of linear chromosomes and the genomes of some DNA viruses. As with RNA, in the...