Stephen C Pak
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Explore the profile of Stephen C Pak including associated specialties, affiliations and a list of published articles.
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53
Citations
3856
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Recent Articles
21.
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
Wang Y, Cobanoglu M, Li J, Hidvegi T, Hale P, Ewing M, et al.
PLoS One
. 2019 Jan;
14(1):e0209748.
PMID: 30673724
The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals. In...
22.
Liu B, Oltvai Z, Bayir H, Silverman G, Pak S, Perlmutter D, et al.
Sci Rep
. 2017 Dec;
7(1):17605.
PMID: 29242632
Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death. Stress signals can...
23.
Markovina S, Wang S, Henke L, Luke C, Pak S, DeWees T, et al.
Br J Cancer
. 2017 Nov;
118(1):72-78.
PMID: 29112685
Background: Pretreatment serum squamous cell carcinoma antigen (SCCA) is a prognostic biomarker in women with cervical cancer. SCCA has not been evaluated as an early indicator of response to chemoradiation...
24.
OReilly L, Knoerdel R, Silverman G, Pak S
Methods Mol Biol
. 2016 Sep;
1470:151-62.
PMID: 27581291
RNA interference (RNAi) is a process in which double-stranded RNA (dsRNA) molecules mediate the inhibition of gene expression. RNAi in C. elegans can be achieved by simply feeding animals with...
25.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
26.
Cummings E, OReilly L, King D, Silverman R, Miedel M, Luke C, et al.
PLoS One
. 2015 Oct;
10(10):e0141542.
PMID: 26512890
α1-antitrypsin deficiency (ATD) predisposes patients to both loss-of-function (emphysema) and gain-of-function (liver cirrhosis) phenotypes depending on the type of mutation. Although the Z mutation (ATZ) is the most prevalent cause...
27.
Niehaus J, Miedel M, Good M, Wyatt A, Pak S, Silverman G, et al.
Biochemistry
. 2015 Oct;
54(45):6756-9.
PMID: 26497600
The clade B/intracellular serpins protect cells from peptidase-mediated injury by forming covalent complexes with their targets. SERPINB12 is expressed in most tissues, especially at cellular interfaces with the external environment....
28.
Hidvegi T, Stolz D, Alcorn J, Yousem S, Wang J, Leme A, et al.
J Biol Chem
. 2015 Oct;
290(50):29742-57.
PMID: 26494620
Recent studies have shown that autophagy mitigates the pathological effects of proteinopathies in the liver, heart, and skeletal muscle but this has not been investigated for proteinopathies that affect the...
29.
Silverman R, Cummings E, OReilly L, Miedel M, Silverman G, Luke C, et al.
Genetics
. 2015 Mar;
200(1):207-19.
PMID: 25786854
Familial encephalopathy with neuroserpin inclusions bodies (FENIB) is a serpinopathy that induces a rare form of presenile dementia. Neuroserpin contains a classical signal peptide and like all extracellular serine proteinase...
30.
Kobet R, Pan X, Zhang B, Pak S, Asch A, Lee M
Biomol Ther (Seoul)
. 2014 Nov;
22(5):371-83.
PMID: 25414766
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional...