Stephen C Kales
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Explore the profile of Stephen C Kales including associated specialties, affiliations and a list of published articles.
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33
Citations
692
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Recent Articles
1.
Pal S, Nance K, Joshi D, Kales S, Ye L, Hu X, et al.
J Chem Inf Model
. 2025 Jan;
65(3):1338-1356.
PMID: 39818814
The global impact of SARS-CoV-2 highlights the need for treatments beyond vaccination, given the limited availability of effective medications. While Pfizer introduced , an FDA-approved antiviral targeting the SARS-CoV-2 main...
2.
DiCiaccio B, Seehawer M, Li Z, Patmanidis A, Bui T, Foidart P, et al.
Cell Rep
. 2024 Nov;
43(12):114991.
PMID: 39570746
We previously described that the KDM5B histone H3 lysine 4 demethylase is an oncogene in estrogen-receptor-positive breast cancer. Here, we report that KDM5A is amplified and overexpressed in basal breast...
3.
Hoxie N, Qiu Y, Kales S, Schneider R, Hu X, Dalal A, et al.
Rapid Commun Mass Spectrom
. 2024 Jun;
e9772.
PMID: 38867136
Rationale: Glutamate carboxypeptidase II (GCPII) catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to yield glutamate (Glu) and N-acetylaspartate (NAA). Inhibition of GCPII has been shown to remediate the neurotoxicity of excess...
4.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2249-2258.
PMID: 37737090
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
5.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
bioRxiv
. 2023 Jun;
PMID: 37292747
The human acetyltransferase paralogs EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
6.
Paul D, Kales S, Cornwell J, Afifi M, Rai G, Zakharov A, et al.
Nat Commun
. 2022 Oct;
13(1):6364.
PMID: 36289220
The F-box protein beta-transducin repeat containing protein (β-TrCP) acts as a substrate adapter for the SCF E3 ubiquitin ligase complex, plays a crucial role in cell physiology, and is often...
7.
Scoles D, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa K, et al.
J Biol Chem
. 2022 Jul;
298(8):102228.
PMID: 35787375
CAG repeat expansions in the ATXN2 (ataxin-2) gene can cause the autosomal dominant disorder spinocerebellar ataxia type 2 (SCA2) as well as increase the risk of ALS. Abnormal molecular, motor,...
8.
Shrimp J, Janiszewski J, Chen C, Xu M, Wilson K, Kales S, et al.
ACS Infect Dis
. 2022 Jun;
8(6):1191-1203.
PMID: 35648838
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allows...
9.
Shrimp J, Janiszewski J, Chen C, Xu M, Wilson K, Kales S, et al.
bioRxiv
. 2022 Feb;
PMID: 35169799
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allowed...
10.
Gandelman M, Dansithong W, Kales S, Paul S, Maag G, Aoyama E, et al.
J Biol Chem
. 2021 Sep;
297(4):101191.
PMID: 34520759
Accumulation of α-synuclein is a main underlying pathological feature of Parkinson's disease and α-synucleinopathies, for which lowering expression of the α-synuclein gene (SNCA) is a potential therapeutic avenue. Using a...