David J Maloney
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Explore the profile of David J Maloney including associated specialties, affiliations and a list of published articles.
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108
Citations
3195
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Recent Articles
1.
Kaylan K, Nargis T, Figatner K, Wang J, Pratuangtham S, Chakraborty A, et al.
bioRxiv
. 2025 Jan;
PMID: 39868153
Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes (T2D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of pro-inflammatory...
2.
Nargis T, Muralidharan C, Enriquez J, Wang J, Kaylan K, Chakraborty A, et al.
JCI Insight
. 2024 Nov;
9(24).
PMID: 39531315
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems....
3.
Nargis T, Muralidharan C, Enriquez J, Wang J, Kaylan K, Chakraborty A, et al.
bioRxiv
. 2024 Aug;
PMID: 39091839
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems....
4.
Renna S, Zhao X, Kunapuli S, Ma P, Holinstat M, Boxer M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(10):1808-1817.
PMID: 37345522
Background: Heparin-induced thrombocytopenia (HIT) is a major concern for all individuals that undergo cardiac bypass surgeries or require prolonged heparin exposure. HIT is a life- and limb-threatening adverse drug reaction...
5.
Imayoshi N, Yoshioka M, Tanaka K, Yang S, Akahane K, Toda Y, et al.
Biochem Biophys Res Commun
. 2021 Dec;
590:49-54.
PMID: 34971957
Acute lymphoblastic leukemia with chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene (MLL-r ALL) remains an incurable disease. Thus, development of a safe and effective therapeutic agent to treat this...
6.
Noguchi T, Hidaka K, Kobayashi S, Matsumoto K, Yoshioka M, Hu X, et al.
Drug Dev Res
. 2021 Jun;
82(8):1235-1246.
PMID: 34075610
Inhibitors of bromodomain and extra-terminal motif (BET) proteins are emerging epigenetic therapeutics that suppress gene expressions that drive cancer and inflammation. The present study examined anti-inflammatory effects of a quinazoline-based...
7.
Christov P, Kim K, Jana S, Romaine I, Rai G, Mott B, et al.
Bioorg Med Chem Lett
. 2021 Mar;
41:127974.
PMID: 33771585
Lactate dehydrogenase (LDH) is a critical enzyme in the glycolytic metabolism pathway that is used by many tumor cells. Inhibitors of LDH may be expected to inhibit the metabolic processes...
8.
Dorjsuren D, Eastman R, Wicht K, Jansen D, Talley D, Sigmon B, et al.
Sci Rep
. 2021 Jan;
11(1):2121.
PMID: 33483532
The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We...
9.
Rai G, Urban D, Mott B, Hu X, Yang S, Benavides G, et al.
J Med Chem
. 2020 Sep;
63(19):10984-11011.
PMID: 32902275
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important...
10.
Oshima N, Ishida R, Kishimoto S, Beebe K, Brender J, Yamamoto K, et al.
Cell Rep
. 2020 Feb;
30(6):1798-1810.e4.
PMID: 32049011
The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo...