Stephen A Ward
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Explore the profile of Stephen A Ward including associated specialties, affiliations and a list of published articles.
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162
Citations
3339
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Recent Articles
11.
Stachulski A, Taujanskas J, Pate S, Rajoli R, Aljayyoussi G, Pennington S, et al.
ACS Infect Dis
. 2020 Dec;
7(6):1317-1331.
PMID: 33352056
The rapidly growing COVID-19 pandemic is the most serious global health crisis since the "Spanish flu" of 1918. There is currently no proven effective drug treatment or prophylaxis for this...
12.
Rajoli R, Pertinez H, Arshad U, Box H, Tatham L, Curley P, et al.
medRxiv
. 2020 Jun;
PMID: 32511548
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials...
13.
Arshad U, Pertinez H, Box H, Tatham L, Rajoli R, Curley P, et al.
Clin Pharmacol Ther
. 2020 May;
108(4):775-790.
PMID: 32438446
There is a rapidly expanding literature on the in vitro antiviral activity of drugs that may be repurposed for therapy or chemoprophylaxis against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). However,...
14.
Klinkhamhom A, Glaharn S, Srisook C, Ampawong S, Krudsood S, Ward S, et al.
Malar J
. 2020 May;
19(1):182.
PMID: 32414377
Background: Pulmonary oedema (PE) is a serious complication of Plasmodium falciparum malaria which can lead to acute lung injury in severe cases. Lung macrophages are activated during malaria infection due...
15.
Yu P, Yang J, Yan J, Meng Z, Hong W, Roberts A, et al.
Spectrochim Acta A Mol Biomol Spectrosc
. 2020 Mar;
234:118257.
PMID: 32208355
The rapid detection of β-lactamases (Blas) and effective screening of Bla inhibitors are critically important and urgent for solving antibiotic resistance and improving precision medicine. Here a novel fluorescent probe...
16.
Birgersson S, Valea I, Tinto H, Traore-Coulibaly M, Toe L, Hoglund R, et al.
Wellcome Open Res
. 2020 Feb;
4:45.
PMID: 32025570
: Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial...
17.
Ehrens A, Lunde C, Jacobs R, Struever D, Koschel M, Frohberger S, et al.
PLoS Negl Trop Dis
. 2020 Jan;
14(1):e0007957.
PMID: 31986143
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo...
18.
Nkhoma S, Trevino S, Gorena K, Nair S, Khoswe S, Jett C, et al.
Cell Host Microbe
. 2020 Jan;
27(1):93-103.e4.
PMID: 31901523
In high-transmission regions, we expect parasite lineages within complex malaria infections to be unrelated due to parasite inoculations from different mosquitoes. This project was designed to test this prediction. We...
19.
Donnellan S, Aljayyoussi G, Moyo E, Ardrey A, Martinez-Rodriguez C, Ward S, et al.
Antimicrob Agents Chemother
. 2019 Oct;
64(1).
PMID: 31611354
Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates based on their predicted clinical efficacy...
20.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
Hubner M, Koschel M, Struever D, Nikolov V, Frohberger S, Ehrens A, et al.
PLoS Negl Trop Dis
. 2019 Aug;
13(8):e0007636.
PMID: 31381563
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083...