Stephanie Oerum
Overview
Explore the profile of Stephanie Oerum including associated specialties, affiliations and a list of published articles.
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15
Citations
465
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Recent Articles
1.
Meynier V, Hardwick S, Catala M, Roske J, Oerum S, Chirgadze D, et al.
Nat Commun
. 2024 Jun;
15(1):4683.
PMID: 38824131
The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by...
2.
Meynier V, Iannazzo L, Catala M, Oerum S, Braud E, Atdjian C, et al.
Nucleic Acids Res
. 2022 May;
50(10):5793-5806.
PMID: 35580049
Chemical synthesis of RNA conjugates has opened new strategies to study enzymatic mechanisms in RNA biology. To gain insights into poorly understood RNA nucleotide methylation processes, we developed a new...
3.
Hochberg I, Demain L, Richer J, Thompson K, Urquhart J, Rea A, et al.
Am J Hum Genet
. 2021 Oct;
108(11):2195-2204.
PMID: 34715011
Human mitochondrial RNase P (mt-RNase P) is responsible for 5' end processing of mitochondrial precursor tRNAs, a vital step in mitochondrial RNA maturation, and is comprised of three protein subunits:...
4.
Oerum S, Meynier V, Catala M, Tisne C
Nucleic Acids Res
. 2021 May;
49(13):7239-7255.
PMID: 34023900
Gene expression is regulated at many levels including co- or post-transcriptionally, where chemical modifications are added to RNA on riboses and bases. Expression control via RNA modifications has been termed...
5.
Lulla V, Wandel M, Bandyra K, Ulferts R, Wu M, Dendooven T, et al.
J Virol
. 2021 May;
95(14):e0066321.
PMID: 33963053
RNA structural elements occur in numerous single-stranded positive-sense RNA viruses. The stem-loop 2 motif (s2m) is one such element with an unusually high degree of sequence conservation, being found in...
6.
Kalnina L, Mateu-Regue A, Oerum S, Hald A, Gerstoft J, Oerum H, et al.
APMIS
. 2021 Mar;
129(7):393-400.
PMID: 33730407
The SARS-CoV-2 pandemic has created an urgent need for diagnostic tests to detect viral RNA. Commercial RNA extraction kits are often expensive, in limited supply, and do not always fully...
7.
Oerum S, Catala M, Bourguet M, Gilet L, Barraud P, Cianferani S, et al.
RNA Biol
. 2021 Feb;
18(11):1996-2006.
PMID: 33541205
All species transcribe ribosomal RNA in an immature form that requires several enzymes for processing into mature rRNA. The number and types of enzymes utilized for these processes vary greatly...
8.
Oerum S, Dendooven T, Catala M, Gilet L, Degut C, Trinquier A, et al.
Mol Cell
. 2020 Sep;
80(2):227-236.e5.
PMID: 32991829
The pathways for ribosomal RNA (rRNA) maturation diverge greatly among the domains of life. In the Gram-positive model bacterium, Bacillus subtilis, the final maturation steps of the two large ribosomal...
9.
Oerum S, Catala M, Atdjian C, Brachet F, Ponchon L, Barraud P, et al.
RNA Biol
. 2019 Mar;
16(6):798-808.
PMID: 30879411
RNA methyltransferases (MTases) catalyse the transfer of a methyl group to their RNA substrates using most-often S-adenosyl-L-methionine (SAM) as cofactor. Only few RNA-bound MTases structures are currently available due to...
10.
Oerum S, Roovers M, Rambo R, Kopec J, Bailey H, Fitzpatrick F, et al.
J Biol Chem
. 2018 Jun;
293(33):12862-12876.
PMID: 29880640
Mitochondrial tRNAs are transcribed as long polycistronic transcripts of precursor tRNAs and undergo posttranscriptional modifications such as endonucleolytic processing and methylation required for their correct structure and function. Among them,...