Stephanie C Huelga
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Explore the profile of Stephanie C Huelga including associated specialties, affiliations and a list of published articles.
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13
Citations
2327
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Recent Articles
1.
Batra R, Stark T, Clark A, Belzile J, Wheeler E, Yee B, et al.
Nat Struct Mol Biol
. 2016 Nov;
23(12):1101-1110.
PMID: 27775709
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results...
2.
Martinez F, Pratt G, Van Nostrand E, Batra R, Huelga S, Kapeli K, et al.
Neuron
. 2016 Oct;
92(4):780-795.
PMID: 27773581
HnRNPA2B1 encodes an RNA binding protein associated with neurodegeneration. However, its function in the nervous system is unclear. Transcriptome-wide crosslinking and immunoprecipitation in mouse spinal cord discover UAGG motifs enriched...
3.
Brannan K, Jin W, Huelga S, Banks C, Gilmore J, Florens L, et al.
Mol Cell
. 2016 Oct;
64(2):282-293.
PMID: 27720645
RNA metabolism is controlled by an expanding, yet incomplete, catalog of RNA-binding proteins (RBPs), many of which lack characterized RNA binding domains. Approaches to expand the RBP repertoire to discover...
4.
Kapeli K, Pratt G, Vu A, Hutt K, Martinez F, Sundararaman B, et al.
Nat Commun
. 2016 Jul;
7:12143.
PMID: 27378374
The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA...
5.
Van Nostrand E, Huelga S, Yeo G
Adv Exp Med Biol
. 2016 Jun;
907:1-28.
PMID: 27256380
After an RNA is transcribed, it undergoes a variety of processing steps that can change the encoded protein sequence (through alternative splicing and RNA editing), regulate the stability of the...
6.
Sundararaman B, Zhan L, Blue S, Stanton R, Elkins K, Olson S, et al.
Mol Cell
. 2016 Mar;
61(6):903-13.
PMID: 26990993
Transcriptome-wide maps of RNA binding protein (RBP)-RNA interactions by immunoprecipitation (IP)-based methods such as RNA IP (RIP) and crosslinking and IP (CLIP) are key starting points for evaluating the molecular...
7.
Scolnick J, Dimon M, Wang I, Huelga S, Amorese D
PLoS One
. 2015 Jul;
10(7):e0128916.
PMID: 26132974
Fusion genes are known to be key drivers of tumor growth in several types of cancer. Traditionally, detecting fusion genes has been a difficult task based on fluorescent in situ...
8.
Arnold E, Ling S, Huelga S, Lagier-Tourenne C, Polymenidou M, Ditsworth D, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(8):E736-45.
PMID: 23382207
Transactivating response region DNA binding protein (TDP-43) is the major protein component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with ubiquitinated inclusions. Two...
9.
Lagier-Tourenne C, Polymenidou M, Hutt K, Vu A, Baughn M, Huelga S, et al.
Nat Neurosci
. 2012 Oct;
15(11):1488-97.
PMID: 23023293
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS binds to RNAs from >5,500 genes in...
10.
Wilbert M, Huelga S, Kapeli K, Stark T, Liang T, Chen S, et al.
Mol Cell
. 2012 Sep;
48(2):195-206.
PMID: 22959275
LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct...