Stephane Gesta
Overview
Explore the profile of Stephane Gesta including associated specialties, affiliations and a list of published articles.
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30
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2929
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Recent Articles
1.
Pellegrino N, Guven A, Gray K, Shah P, Kasture G, Nastke M, et al.
Int J Mol Sci
. 2022 Apr;
23(7).
PMID: 35408841
Post-translational modifications of proteins ensure optimized cellular processes, including proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced homeostatic state. Abnormal post-translational modifications are associated with cellular...
2.
Arsenault H, Ghizzoni J, Leech C, Diers A, Gesta S, Vishnudas V, et al.
G3 (Bethesda)
. 2021 Sep;
11(12).
PMID: 34586382
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the...
3.
Dadali T, Diers A, Kazerounian S, Muthuswamy S, Awate P, Ng R, et al.
Sci Rep
. 2021 Mar;
11(1):5749.
PMID: 33707480
Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for...
4.
Sun J, Patel C, Jang T, Merchant M, Chen C, Kazerounian S, et al.
Sci Rep
. 2020 Aug;
10(1):13899.
PMID: 32807842
Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant...
5.
Guven A, Wu W, Patil S, Gokul K, Tekumalla P, Sharma S, et al.
J Pharm Biomed Anal
. 2019 May;
173:40-46.
PMID: 31108422
Ubiquitin plays an essential role in modulating protein function, and deregulation of the ubiquitin system leads to the development of a variety of human diseases. E3 Ubiquitin ligases that mediate...
6.
Thapa K, Wu K, Sarma A, Grund E, Szeto A, Mendez A, et al.
Cell Biosci
. 2018 Aug;
8:45.
PMID: 30140426
Background: Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium...
7.
Jing E, Sundararajan P, Majumdar I, Hazarika S, Fowler S, Szeto A, et al.
Nutr Metab (Lond)
. 2018 Feb;
15:11.
PMID: 29434648
Background: Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as...
8.
Yang J, Hagen J, Guntur K, Allette K, Schuyler S, Ranjan J, et al.
BMC Genomics
. 2017 Dec;
18(1):987.
PMID: 29273013
Background: Exosomes and other extracellular vesicles (EVs) have emerged as an important mechanism of cell-to-cell communication. However, previous studies either did not fully resolve what genetic materials were shuttled by...
9.
Dowal L, Parameswaran P, Phat S, Akella S, Majumdar I, Ranjan J, et al.
Mediators Inflamm
. 2017 May;
2017:9067049.
PMID: 28458470
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized...
10.
Narain N, Diers A, Lee A, Lao S, Chan J, Schofield S, et al.
Future Sci OA
. 2017 Mar;
3(1):FSO161.
PMID: 28344825
Aim: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. Materials & Methods: perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in models and...