Jeremie Boucher
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Explore the profile of Jeremie Boucher including associated specialties, affiliations and a list of published articles.
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63
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4481
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Recent Articles
1.
Cypess A, Cannon B, Nedergaard J, Kazak L, Chang D, Krakoff J, et al.
Cell Metab
. 2024 Dec;
37(1):12-33.
PMID: 39644896
Until two decades ago, brown adipose tissue (BAT) was studied primarily as a thermogenic organ of small rodents in the context of cold adaptation. The discovery of functional human BAT...
2.
Park S, Fadhul T, Conroy L, Clarke H, Sun R, Wallenius K, et al.
JCI Insight
. 2024 Oct;
9(23).
PMID: 39418102
Excessive fructose intake is a risk factor for the development of obesity and its complications. Targeting ketohexokinase (KHK), the first enzyme of fructose metabolism, has been investigated for the management...
3.
Kroon T, Hagstedt T, Alexandersson I, Ferm A, Petersson M, Maurer S, et al.
Sci Transl Med
. 2022 Oct;
14(668):eabh1316.
PMID: 36288279
Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK...
4.
Borgeson E, Boucher J, Hagberg C
Front Cell Dev Biol
. 2022 Oct;
10:1003118.
PMID: 36187476
The prevalence of obesity and metabolic diseases continues to rise, which has led to an increased interest in studying adipose tissue to elucidate underlying disease mechanisms. The use of genetic...
5.
Bonnet L, Alexandersson I, Baboota R, Kroon T, Oscarsson J, Smith U, et al.
Front Endocrinol (Lausanne)
. 2022 Sep;
13:957616.
PMID: 36072934
Cellular senescence is a state of irreversible cell cycle arrest and has been shown to play a key role in many diseases, including metabolic diseases. To investigate the potential contribution...
6.
Baboota R, Rawshani A, Bonnet L, Li X, Yang H, Mardinoglu A, et al.
Nat Metab
. 2022 Aug;
4(8):1007-1021.
PMID: 35995996
The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed liver biopsies and extensive...
7.
Baboota R, Spinelli R, Erlandsson M, Brandao B, Lino M, Yang H, et al.
Mol Metab
. 2022 Jul;
64:101558.
PMID: 35872305
Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other...
8.
Sotak M, Rajan M, Clark M, Harms M, Rani A, Kraft J, et al.
iScience
. 2022 Jul;
25(7):104602.
PMID: 35789845
Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A, a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammation and subsequently protects...
9.
Wallenius K, Kroon T, Hagstedt T, Lofgren L, Sorhede-Winzell M, Boucher J, et al.
J Lipid Res
. 2022 Feb;
63(3):100176.
PMID: 35120993
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to increase ketone bodies in patients with type 2 diabetes; however, the underlying mechanisms have not been fully elucidated. Here we examined...
10.
Rocha A, Guerra B, Boucher J, Mori M
Bio Protoc
. 2022 Jan;
11(24):e4265.
PMID: 35087924
Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend...