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Stephan Mathas

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Articles 57
Citations 1807
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Recent Articles
21.
Edginton-White B, Cauchy P, Assi S, Hartmann S, Riggs A, Mathas S, et al.
Leukemia . 2018 Dec; 33(6):1463-1474. PMID: 30546079
Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as promoters and enhancers. Their expression is therefore under tight epigenetic control. We...
22.
Schleussner N, Merkel O, Costanza M, Liang H, Hummel F, Romagnani C, et al.
Leukemia . 2018 Mar; 32(9):1994-2007. PMID: 29588546
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK and ALK anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in...
23.
Eichenauer D, Plutschow A, Kreissl S, Sokler M, Hellmuth J, Meissner J, et al.
Lancet Oncol . 2017 Nov; 18(12):1680-1687. PMID: 29133014
Background: A high proportion of patients with relapsed classical Hodgkin's lymphoma achieve a response with the antibody-drug conjugate brentuximab vedotin, and the drug is well tolerated. We modified the escalated...
24.
Du J, Neuenschwander M, Yu Y, Dabritz J, Neuendorff N, Schleich K, et al.
Blood . 2016 Oct; 129(1):71-81. PMID: 27733358
Classical Hodgkin lymphoma (cHL), although originating from B cells, is characterized by the virtual lack of gene products whose expression constitutes the B-cell phenotype. Epigenetic repression of B-cell-specific genes via...
25.
Mathas S, Hartmann S, Kuppers R
Semin Hematol . 2016 Aug; 53(3):139-47. PMID: 27496304
The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular lymphocyte predominant HL (NLPHL), are derived from mature...
26.
de Oliveira K, Kaergel E, Heinig M, Fontaine J, Patone G, Muro E, et al.
Genome Med . 2016 Mar; 8(1):28. PMID: 26988706
Background: NF-κB is widely involved in lymphoid malignancies; however, the functional roles and specific transcriptomes of NF-κB dimers with distinct subunit compositions have been unclear. Methods: Using combined ChIP-sequencing and...
27.
Roukos V, Mathas S
Front Biosci (Schol Ed) . 2015 May; 7(2):260-8. PMID: 25961701
Translocations involving the anaplastic lymphoma kinase (ALK) gene locus on chromosome 2p23 were first described in anaplastic large cell lymphoma (ALCL). Although most commonly fused to the nucleophosmin (NPM1) gene...
28.
Kreher S, Cauchy P, Bonifer C, Mathas S
Cytokine . 2015 Jan; 72(1):115-7. PMID: 25585876
No abstract available.
29.
Behringer K, Goergen H, Hitz F, Zijlstra J, Greil R, Markova J, et al.
Lancet . 2014 Dec; 385(9976):1418-27. PMID: 25539730
Background: The role of bleomycin and dacarbazine in the ABVD regimen (ie, doxorubicin, bleomycin, vinblastine, and dacarbazine) has been questioned, especially for treatment of early-stage favourable Hodgkin's lymphoma, because of...
30.
Weilemann A, Grau M, Erdmann T, Merkel O, Sobhiafshar U, Anagnostopoulos I, et al.
Blood . 2014 Nov; 125(1):124-32. PMID: 25359993
Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK(+)...