Stephan L M Peters
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Explore the profile of Stephan L M Peters including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Meijers J, Bakhtiari K, Zwiers A, Peters S
Thromb Res
. 2023 May;
227:17-24.
PMID: 37207560
Background: Antithrombotic therapy is inevitably associated with a risk for bleeding and these bleeding complications can be life-threatening. Recently, specific reversal agents were developed for the direct factor Xa and...
2.
Amraoui F, Hassani Lahsinoui H, Spijkers L, Vogt L, Peters S, Wijesinghe D, et al.
Pregnancy Hypertens
. 2020 Jan;
19:100-105.
PMID: 31927322
Objectives: Ceramide is a sphingolipid with anti-angiogenic and pro-apoptotic properties that has shown to be increased in plasma of women with pre-eclampsia. We aimed to compare plasma and placental sphingolipid...
3.
Keul P, Van Borren M, Ghanem A, Muller F, Baartscheer A, Verkerk A, et al.
J Am Heart Assoc
. 2016 May;
5(5).
PMID: 27207969
Background: Sphingosine-1-phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia-reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine-1-phosphate receptor 1 (S1P1) in vivo is unknown. Methods And Results:...
4.
van Hooren K, Spijkers L, van Breevoort D, Fernandez-Borja M, Bierings R, van Buul J, et al.
PLoS One
. 2014 Mar;
9(3):e91346.
PMID: 24632890
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces...
5.
van den Elsen L, Spijkers L, van den Akker R, van Winssen A, Balvers M, Wijesinghe D, et al.
J Hypertens
. 2014 Feb;
32(5):1050-8.
PMID: 24569415
Objective: Long-chain n-3 polyunsaturated fatty acids from oily fish reduce blood pressure (BP) in hypertension. Previously, we demonstrated that hypertension is associated with marked alterations in sphingolipid biology and elevated...
6.
Spijkers L, Alewijnse A, Peters S
Br J Pharmacol
. 2012 Jan;
166(4):1411-8.
PMID: 22251137
Background And Purpose: FTY720 (Fingolimod) is a recently approved orally administered drug for the treatment of multiple sclerosis. Phase II and III clinical trials have demonstrated that this drug modestly...
7.
Spijkers L, Janssen B, Nelissen J, Meens M, Wijesinghe D, Chalfant C, et al.
PLoS One
. 2011 Dec;
6(12):e29222.
PMID: 22195025
Background: We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation...
8.
Spijkers L, van den Akker R, Janssen B, Debets J, De Mey J, Stroes E, et al.
PLoS One
. 2011 Aug;
6(7):e21817.
PMID: 21818267
Background: Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid...
9.
van Loenen P, de Graaf C, Verzijl D, Leurs R, Rognan D, Peters S, et al.
Eur J Pharmacol
. 2011 Jun;
667(1-3):105-12.
PMID: 21663738
The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the...
10.
Frazier E, Michel-Reher M, van Loenen P, Sand C, Schneider T, Peters S, et al.
Eur J Pharmacol
. 2010 Dec;
654(1):86-91.
PMID: 21172342
Nebivolol is a selective β₁-adrenoceptor antagonist which, in addition, displays endothelium-dependent vasodilating properties in humans and other species. β₃-adrenoceptors have been proposed to be a molecular target of nebivolol-induced vasodilatation....