Astrid E Alewijnse
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Explore the profile of Astrid E Alewijnse including associated specialties, affiliations and a list of published articles.
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30
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742
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Recent Articles
1.
Keul P, Van Borren M, Ghanem A, Muller F, Baartscheer A, Verkerk A, et al.
J Am Heart Assoc
. 2016 May;
5(5).
PMID: 27207969
Background: Sphingosine-1-phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia-reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine-1-phosphate receptor 1 (S1P1) in vivo is unknown. Methods And Results:...
2.
van Hooren K, Spijkers L, van Breevoort D, Fernandez-Borja M, Bierings R, van Buul J, et al.
PLoS One
. 2014 Mar;
9(3):e91346.
PMID: 24632890
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces...
3.
van den Elsen L, Spijkers L, van den Akker R, van Winssen A, Balvers M, Wijesinghe D, et al.
J Hypertens
. 2014 Feb;
32(5):1050-8.
PMID: 24569415
Objective: Long-chain n-3 polyunsaturated fatty acids from oily fish reduce blood pressure (BP) in hypertension. Previously, we demonstrated that hypertension is associated with marked alterations in sphingolipid biology and elevated...
4.
Tobia C, Chiodelli P, Nicoli S, DellEra P, Buraschi S, Mitola S, et al.
Arterioscler Thromb Vasc Biol
. 2012 Jul;
32(9):e104-16.
PMID: 22837470
Objective: Endothelial sphingosine-1-phosphate (S1P) receptor-1 (S1P(1)) affects different vascular functions, including blood vessel maturation and permeability. Here, we characterized the role of the zS1P(1) ortholog in vascular development in zebrafish....
5.
Spijkers L, Alewijnse A, Peters S
Br J Pharmacol
. 2012 Jan;
166(4):1411-8.
PMID: 22251137
Background And Purpose: FTY720 (Fingolimod) is a recently approved orally administered drug for the treatment of multiple sclerosis. Phase II and III clinical trials have demonstrated that this drug modestly...
6.
Spijkers L, Janssen B, Nelissen J, Meens M, Wijesinghe D, Chalfant C, et al.
PLoS One
. 2011 Dec;
6(12):e29222.
PMID: 22195025
Background: We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation...
7.
Spijkers L, van den Akker R, Janssen B, Debets J, De Mey J, Stroes E, et al.
PLoS One
. 2011 Aug;
6(7):e21817.
PMID: 21818267
Background: Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid...
8.
van Loenen P, de Graaf C, Verzijl D, Leurs R, Rognan D, Peters S, et al.
Eur J Pharmacol
. 2011 Jun;
667(1-3):105-12.
PMID: 21663738
The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the...
9.
van Doorn R, van Horssen J, Verzijl D, Witte M, Ronken E, van Het Hof B, et al.
Glia
. 2010 Jul;
58(12):1465-76.
PMID: 20648639
Sphingolipids are a class of biologically active lipids that have a role in multiple biological processes including inflammation. Sphingolipids exert their functions by direct signaling or through signaling by their...
10.
Verzijl D, Peters S, Alewijnse A
Mol Cells
. 2010 Feb;
29(2):99-104.
PMID: 20127285
Regulatory processes including receptor phosphorylation and intracellular trafficking, also referred to as receptor internalization, are important processes to terminate G protein-coupled receptor (GPCR) signaling. Compelling evidence now indicates that internalization...