Stefanie R Mullins
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Explore the profile of Stefanie R Mullins including associated specialties, affiliations and a list of published articles.
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10
Citations
588
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Recent Articles
1.
Zanker D, Spurling A, Brockwell N, Owen K, Zakhour J, Robinson T, et al.
Clin Transl Immunology
. 2020 Oct;
9(9):e1177.
PMID: 33005415
Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple-negative...
2.
Mullins S, Vasilakos J, Deschler K, Grigsby I, Gillis P, John J, et al.
J Immunother Cancer
. 2019 Sep;
7(1):244.
PMID: 31511088
Background: Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically "cold" tumors, tumor-resident innate immune cell activation may be required...
3.
Xie B, Tomaszewski M, Neves A, Ros S, Hu D, McGuire S, et al.
Clin Cancer Res
. 2017 Aug;
23(22):6893-6903.
PMID: 28821560
The development of new treatments and their deployment in the clinic may be assisted by imaging methods that allow an early assessment of treatment response in individual patients. The C2A...
4.
Mullins S, Sameni M, Blum G, Bogyo M, Sloane B, Moin K
Biol Chem
. 2013 May;
393(12):1405-16.
PMID: 23667900
The expression of the cysteine protease cathepsin B is increased in early stages of human breast cancer.To assess the potential role of cathepsin B in premalignant progression of breast epithelial...
5.
Zhang J, Valianou M, Simmons H, Robinson M, Lee H, Mullins S, et al.
FASEB J
. 2012 Oct;
27(2):581-9.
PMID: 23104982
Fibroblast activation protein (FAP) is a serine protease selectively expressed on tumor stromal fibroblasts in epithelial carcinomas and is important in cancer growth, adhesion, and metastases. As FAP enzymatic activity...
6.
Lee H, Mullins S, Franco-Barraza J, Valianou M, Cukierman E, Cheng J
BMC Cancer
. 2011 Jun;
11:245.
PMID: 21668992
Background: Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively produced by tumor-associated...
7.
Moin K, Schwartz D, Mullins S, Sloane B
Methods Mol Biol
. 2009 Apr;
539:49-57.
PMID: 19377971
Expression of a given protease and of the endogenous inhibitors that regulate protease activity can be readily determined at the transcript level by using whole genome microarray chips. In the...
8.
Sameni M, Cavallo-Medved D, Dosescu J, Jedeszko C, Moin K, Mullins S, et al.
Clin Exp Metastasis
. 2008 Dec;
26(4):299-309.
PMID: 19082919
The roles of proteases in cancer are dynamic. Furthermore, the roles or functions of any one protease may differ from one stage of cancer to another. Proteases from tumor-associated cells...
9.
Narra K, Mullins S, Lee H, Strzemkowski-Brun B, Magalong K, Christiansen V, et al.
Cancer Biol Ther
. 2007 Nov;
6(11):1691-9.
PMID: 18032930
Purpose: Fibroblast Activation Protein (FAP) is a tumor fibroblast protease that has been shown to potentiate colorectal cancer growth. The clinical impact of FAP inhibition was tested using Val-boroPro (Talabostat),...
10.
Blum G, Mullins S, Keren K, Fonovic M, Jedeszko C, Rice M, et al.
Nat Chem Biol
. 2006 Jan;
1(4):203-9.
PMID: 16408036
Protease activity is tightly regulated in both normal and disease conditions. However, it is often difficult to monitor the dynamic nature of this regulation in the context of a live...