Christopher Jedeszko
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Explore the profile of Christopher Jedeszko including associated specialties, affiliations and a list of published articles.
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12
Citations
495
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Recent Articles
1.
Slattery S, Giguere D, Stuckless E, Shrestha A, Briere L, Galbraith A, et al.
Sci Rep
. 2022 Apr;
12(1):7010.
PMID: 35487958
The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in...
2.
Jedeszko C, Paez-Ribes M, Di Desidero T, Man S, Lee C, Xu P, et al.
Sci Transl Med
. 2015 Apr;
7(282):282ra50.
PMID: 25855496
Renal cell carcinoma (RCC), normally considered an intrinsically chemotherapy-resistant cancer, is currently treated with targeted biologic therapies, including antiangiogenic tyrosine kinase inhibitors (TKIs), such as pazopanib. The efficacy of these...
3.
Ebos J, Mastri M, Lee C, Tracz A, Hudson J, Attwood K, et al.
EMBO Mol Med
. 2014 Nov;
6(12):1561-76.
PMID: 25361689
Thousands of cancer patients are currently in clinical trials evaluating antiangiogenic therapy in the neoadjuvant setting, which is the treatment of localized primary tumors prior to surgical intervention. The rationale...
4.
Caglic D, Repnik U, Jedeszko C, Kosec G, Miniejew C, Kindermann M, et al.
Biol Chem
. 2012 Nov;
394(2):307-16.
PMID: 23152404
Osteoarthritis and rheumatoid arthritis are destructive joint diseases that involve the loss of articular cartilage. Degradation of cartilage extracellular matrix is believed to occur due to imbalance between the catabolic...
5.
Jedeszko C, Victor B, Podgorski I, Sloane B
Cancer Res
. 2009 Nov;
69(23):9148-55.
PMID: 19920187
Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the regulation of tumor cell migration and invasion. The...
6.
Sameni M, Cavallo-Medved D, Dosescu J, Jedeszko C, Moin K, Mullins S, et al.
Clin Exp Metastasis
. 2008 Dec;
26(4):299-309.
PMID: 19082919
The roles of proteases in cancer are dynamic. Furthermore, the roles or functions of any one protease may differ from one stage of cancer to another. Proteases from tumor-associated cells...
7.
Jedeszko C, Sameni M, Olive M, Moin K, Sloane B
Curr Protoc Cell Biol
. 2008 Jun;
Chapter 4:Unit 4.20.
PMID: 18551423
Proteolytic degradation of extracellular matrix (ECM) components by cells is an important metabolic activity as cells grow, remodel, and migrate through the ECM. The ability to analyze ECM degradation can...
8.
Blum G, Mullins S, Keren K, Fonovic M, Jedeszko C, Rice M, et al.
Nat Chem Biol
. 2006 Jan;
1(4):203-9.
PMID: 16408036
Protease activity is tightly regulated in both normal and disease conditions. However, it is often difficult to monitor the dynamic nature of this regulation in the context of a live...
9.
Brocard C, Boucher K, Jedeszko C, Kim P, Walton P
Traffic
. 2005 Apr;
6(5):386-95.
PMID: 15813749
Our aim was to determine the role of microtubules in the biogenesis of peroxisomes. Fusion experiments between human PEX16- and PEX1-mutant cells in the presence of nocodazol implied that microtubules...
10.
Podgorski I, Linebaugh B, Sameni M, Jedeszko C, Bhagat S, Cher M, et al.
Neoplasia
. 2005 Apr;
7(3):207-23.
PMID: 15799821
Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DQ-collagen I (a bone matrix protein) and, for comparison, DQ-collagen IV, by living human prostate carcinoma cells...