Stefanie Klima
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Explore the profile of Stefanie Klima including associated specialties, affiliations and a list of published articles.
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14
Citations
233
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Recent Articles
1.
van Heerden D, Klima S, van den Bout I
Curr Opin Cell Biol
. 2023 Dec;
86:102290.
PMID: 38048657
The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification....
2.
Klima S, Brull M, Spreng A, Suciu I, Falt T, Schwamborn J, et al.
Arch Toxicol
. 2021 Mar;
95(5):1703-1722.
PMID: 33713149
Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue,...
3.
Loser D, Schaefer J, Danker T, Moller C, Brull M, Suciu I, et al.
Arch Toxicol
. 2020 Dec;
95(1):229-252.
PMID: 33269408
Prediction of drug toxicity on the human nervous system still relies mainly on animal experiments. Here, we developed an alternative system allowing assessment of complex signaling in both individual human...
4.
Klima S, Suciu I, Hoelting L, Gutbier S, Waldmann T, Dietrich D, et al.
ALTEX
. 2020 Jun;
38(1):73-81.
PMID: 32591837
Microcystins (MC) are a group of cyanobacterial toxins that comprises MC-LF and other cyclic heptapeptides, best known as potent hepatotoxicants. Cell culture and epidemiological studies suggest that MC might also...
5.
Karreman C, Klima S, Holzer A, Leist M
ALTEX
. 2020 Apr;
37(2):332-336.
PMID: 32242642
Quantification of changes in intracellular free Ca2+ concentrations [Ca2+]i is fundamental to the understanding of the physiology of single cells in response to both environmental and endogenous stimuli. Here we...
6.
Kranaster P, Karreman C, Dold J, Krebs A, Funke M, Holzer A, et al.
Arch Toxicol
. 2019 Dec;
94(2):449-467.
PMID: 31828357
While there are many methods to quantify the synthesis, localization, and pool sizes of proteins and DNA during physiological responses and toxicological stress, only few approaches allow following the fate...
7.
Dreser N, Madjar K, Holzer A, Kapitza M, Scholz C, Kranaster P, et al.
Arch Toxicol
. 2019 Nov;
94(1):151-171.
PMID: 31712839
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology tests, e.g. developed during the ESNATS project, use human cells and measure mechanistic endpoints (such...
8.
Bal-Price A, Hogberg H, Crofton K, Daneshian M, FitzGerald R, Fritsche E, et al.
ALTEX
. 2019 Jul;
36(3):506.
PMID: 31329255
In this manuscript, which appeared in ALTEX 35 , 306-352 ( doi:10.14573/altex.1712081 ), the Acknowledgements should read: This work was supported by the Doerenkamp-Zbinden Foundation, EFSA, the BMBF, JPI-NutriCog-Selenius, and...
9.
Delp J, Gutbier S, Klima S, Hoelting L, Pinto-Gil K, Hsieh J, et al.
ALTEX
. 2019 Jul;
36(3):505.
PMID: 31329253
In this manuscript, which appeared in ALTEX 35 , 235-253 ( doi:10.14573/altex.1712182 ), the Acknowledgements should read: This work was supported by the Land BW, the Doerenkamp-Zbinden Foundation, the DFG...
10.
Bal-Price A, Hogberg H, Crofton K, Daneshian M, FitzGerald R, Fritsche E, et al.
ALTEX
. 2018 Feb;
35(3):306-352.
PMID: 29485663
Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The...