Jorg Rahnenfuhrer
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Explore the profile of Jorg Rahnenfuhrer including associated specialties, affiliations and a list of published articles.
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155
Citations
4871
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Recent Articles
1.
Volkert I, Grube J, Woitok M, Mohamed M, Edlund K, Duda J, et al.
Hepatology
. 2025 Feb;
PMID: 40009601
Background And Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is associated with c-Jun N-terminal kinases (JNK) activation across various cell types, but its hepatocyte-specific function in steatotic liver disease remains unclear. Our...
2.
Albrecht W, Brecklinghaus T, Stolte M, Kappenberg F, Grundler L, Chen P, et al.
ALTEX
. 2025 Feb;
PMID: 39955620
Prediction of hepatotoxicity in humans remains an unresolved challenge. Recently, an in-vitro/in-silico-method was established to predict blood concentrations of test compounds with an increased risk of causing human hepatotoxicity. In...
3.
Prince T, Bommert A, Rahnenfuhrer J, Schmid M
PLoS One
. 2025 Jan;
20(1):e0318349.
PMID: 39888901
Inverse probability weighting (IPW) is a popular method for making inferences regarding unobserved or unobservable data of a target population based on observed data. This paper considers IPW applied to...
4.
Rieger J, Jentsch C, Rahnenfuhrer J
PeerJ Comput Sci
. 2024 Dec;
10:e2279.
PMID: 39678270
Latent Dirichlet allocation (LDA) is a popular method for analyzing large text corpora, but it suffers from instability due to its reliance on random initialization. This results in different outcomes...
5.
Jurgens M, Claus M, Wingert S, Alexander Niemann J, Picard L, Hennes E, et al.
Eur J Immunol
. 2024 Oct;
54(12):e2451299.
PMID: 39350450
Adrenergic receptors (ARs) are preferentially expressed by innate lymphocytes such as natural killer (NK) cells. Here, we study the effect of epinephrine-mediated stimulation of the β2-adrenergic receptor (β2AR) on the...
6.
Lodde G, Zhao F, Herbst R, Terheyden P, Utikal J, Pfohler C, et al.
Eur J Cancer
. 2024 Aug;
210:114295.
PMID: 39213786
Background: Immune checkpoint inhibition (ICI) currently is the most effective treatment to induce durable responses in metastatic melanoma. The aims of this study are the characterization of patients with early,...
7.
Stolte M, Schreck N, Slynko A, Saadati M, Benner A, Rahnenfuhrer J, et al.
PLoS One
. 2024 May;
19(5):e0299989.
PMID: 38748677
Simulation is a crucial tool for the evaluation and comparison of statistical methods. How to design fair and neutral simulation studies is therefore of great interest for both researchers developing...
8.
Tug T, Duda J, Menssen M, Bruce S, Bringezu F, Dammann M, et al.
Regul Toxicol Pharmacol
. 2024 Feb;
148:105583.
PMID: 38401761
The alkaline comet assay is frequently used as in vivo follow-up test within different regulatory environments to characterize the DNA-damaging potential of different test items. The corresponding OECD Test guideline...
9.
Duda J, Drenda C, Kastel H, Rahnenfuhrer J, Kappenberg F
Sci Rep
. 2023 Nov;
13(1):20804.
PMID: 38012163
High throughput RNA sequencing experiments are widely conducted and analyzed to identify differentially expressed genes (DEGs). The statistical models calculated for this task are often not clear to practitioners, and...
10.
Ghallab A, Gonzalez D, Strangberg E, Hofmann U, Myllys M, Hassan R, et al.
J Hepatol
. 2023 Nov;
80(2):268-281.
PMID: 37939855
Background & Aims: Cholemic nephropathy (CN) is a severe complication of cholestatic liver diseases for which there is no specific treatment. We revisited its pathophysiology with the aim of identifying...