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» Authors » Margit Henry

Margit Henry

Explore the profile of Margit Henry including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 27
Citations 539
Followers 0
Related Specialties
Cell Biology
Biochemistry
Toxicology
Top 10 Co-Authors
Jurgen Hescheler
Agapios Sachinidis
Marcel Leist
Jorg Rahnenfuhrer
Tanja Waldmann
Tamara Rotshteyn
Toni Schneider
Jan G Hengstler
Marco Weiergraber
Nils Bluthgen
Published In
Arch Toxicol
Cells
Chem Res Toxicol
Cell Physiol Biochem
Mol Endocrinol
Affiliations
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Recent Articles
1.
Transcriptomic and Functional Evidence That miRNA193a-3p Inhibits Lymphatic Endothelial Cell (LEC) and LEC + MCF-7 Spheroid Growth Directly and by Altering MCF-7 Secretome
Azzarito G, Henry M, Rotshteyn T, Leeners B, Dubey R
Cells . 2023 Feb; 12(3). PMID: 36766731
MicroRNA 193a-3p (miR193a-3p) is a short non-coding RNA with tumor suppressor properties. Breast cancer (BC) progression is governed by active interaction between breast cancer cells, vascular (V)/lymphatic (L) endothelial cells...
2.
High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation
Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, et al.
Cells . 2022 Nov; 11(21). PMID: 36359802
Human-relevant tests to predict developmental toxicity are urgently needed. A currently intensively studied approach makes use of differentiating human stem cells to measure chemically-induced deviations of the normal developmental program,...
3.
Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test
Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, et al.
Chem Res Toxicol . 2022 Apr; 35(5):760-773. PMID: 35416653
Despite the progress made in developmental toxicology, there is a great need for in vitro tests that identify developmental toxicants in relation to human oral doses and blood concentrations. In...
4.
Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
Meisig J, Dreser N, Kapitza M, Henry M, Rotshteyn T, Rahnenfuhrer J, et al.
Nucleic Acids Res . 2020 Nov; 48(22):12577-12592. PMID: 33245762
Thousands of transcriptome data sets are available, but approaches for their use in dynamic cell response modelling are few, especially for processes affected simultaneously by two orthogonal influencing variables. We...
5.
Radiation Response of Murine Embryonic Stem Cells
Hellweg C, Shinde V, Srinivasan S, Henry M, Rotshteyn T, Baumstark-Khan C, et al.
Cells . 2020 Jul; 9(7). PMID: 32660081
To understand the mechanisms of disturbed differentiation and development by radiation, murine CGR8 embryonic stem cells (mESCs) were exposed to ionizing radiation and differentiated by forming embryoid bodies (EBs). The...
6.
Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances
Dreser N, Madjar K, Holzer A, Kapitza M, Scholz C, Kranaster P, et al.
Arch Toxicol . 2019 Nov; 94(1):151-171. PMID: 31712839
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology tests, e.g. developed during the ESNATS project, use human cells and measure mechanistic endpoints (such...
7.
Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity
Acharya A, Brungs S, Henry M, Rotshteyn T, Singh Yaduvanshi N, Wegener L, et al.
Stem Cells Dev . 2018 Apr; 27(12):838-847. PMID: 29630478
Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of short-term altered gravity on embryonic development processes, we exposed mouse embryonic stem cells (mESCs)...
8.
Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5
Filipova D, Henry M, Rotshteyn T, Brunn A, Carstov M, Deckert M, et al.
PLoS One . 2018 Mar; 13(3):e0194428. PMID: 29543863
In skeletal muscle the coordinated actions of two mechanically coupled Ca2+ channels-the 1,4-dihydropyridine receptor (Cav1.1) and the type 1 ryanodine receptor (RYR1)-underlie the molecular mechanism of rapid cytosolic [Ca2+] increase...
9.
Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells
Shinde V, Srinivasan S, Henry M, Rotshteyn T, Hescheler J, Rahnenfuhrer J, et al.
Stem Cell Res Ther . 2017 Jan; 7(1):190. PMID: 28038682
Background: Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investigated the...
10.
Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity
Waldmann T, Grinberg M, Konig A, Rempel E, Schildknecht S, Henry M, et al.
Chem Res Toxicol . 2016 Dec; 30(4):905-922. PMID: 28001369
Analysis of transcriptome changes has become an established method to characterize the reaction of cells to toxicants. Such experiments are mostly performed at compound concentrations close to the cytotoxicity threshold....