Stefan Weitzer
Overview
Explore the profile of Stefan Weitzer including associated specialties, affiliations and a list of published articles.
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17
Citations
882
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Recent Articles
1.
Koferle A, Schlattl A, Hormann A, Thatikonda V, Popa A, Spreitzer F, et al.
Cell Rep
. 2022 Apr;
39(2):110636.
PMID: 35417719
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for...
2.
Kroupova A, Ackle F, Asanovic I, Weitzer S, Boneberg F, Faini M, et al.
Elife
. 2021 Dec;
10.
PMID: 34854379
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex...
3.
Sekulovski S, Devant P, Panizza S, Gogakos T, Pitiriciu A, Heitmeier K, et al.
Nat Commun
. 2021 Sep;
12(1):5610.
PMID: 34584079
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur in patients with pontocerebellar...
4.
Asanovic I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, et al.
Mol Cell
. 2021 Apr;
81(12):2520-2532.e16.
PMID: 33930333
The tRNA ligase complex (tRNA-LC) splices precursor tRNAs (pre-tRNA), and Xbp1-mRNA during the unfolded protein response (UPR). In aerobic conditions, a cysteine residue bound to two metal ions in its...
5.
Pinto P, Kroupova A, Schleiffer A, Mechtler K, Jinek M, Weitzer S, et al.
Science
. 2020 Aug;
369(6503):524-530.
PMID: 32732418
RNA molecules are frequently modified with a terminal 2',3'-cyclic phosphate group as a result of endonuclease cleavage, exonuclease trimming, or de novo synthesis. During pre-transfer RNA (tRNA) and unconventional messenger...
6.
Conde C, Petronczki O, Baris S, Willmann K, Girardi E, Salzer E, et al.
J Clin Invest
. 2019 Aug;
129(10):4194-4206.
PMID: 31449058
Polymerase δ is essential for eukaryotic genome duplication and synthesizes DNA at both the leading and lagging strands. The polymerase δ complex is a heterotetramer comprising the catalytic subunit POLD1...
7.
Weitzer S, Hanada T, Penninger J, Martinez J
Wiley Interdiscip Rev RNA
. 2014 Aug;
6(1):47-63.
PMID: 25142875
Defects in RNA metabolic pathways are well-established causes for neurodegenerative disorders. Several mutations in genes involved in pre-messenger RNA (pre-mRNA) and tRNA metabolism, RNA stability and protein translation have been...
8.
Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, et al.
Cell
. 2014 Apr;
157(3):636-50.
PMID: 24766809
CLP1 is a RNA kinase involved in tRNA splicing. Recently, CLP1 kinase-dead mice were shown to display a neuromuscular disorder with loss of motor neurons and muscle paralysis. Human genome...
9.
Mair B, Popow J, Mechtler K, Weitzer S, Martinez J
Biochem Soc Trans
. 2013 Jul;
41(4):831-7.
PMID: 23863140
The process of tRNA splicing entails removal of an intron by TSEN (tRNA-splicing endonuclease) and ligation of the resulting exon halves to generate functional tRNAs. In mammalian cells, the RNA...
10.
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger B, Ichida J, et al.
Nature
. 2013 Mar;
495(7442):474-80.
PMID: 23474986
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1(K/K)) mice that show a progressive...