Frank Uhlmann
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Explore the profile of Frank Uhlmann including associated specialties, affiliations and a list of published articles.
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119
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4914
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Recent Articles
1.
Guerin T, Barrington C, Pobegalov G, Molodtsov M, Uhlmann F
EMBO J
. 2025 Jan;
44(5):1563-1568.
PMID: 39890887
No abstract available.
2.
Guerin T, Barrington C, Pobegalov G, Molodtsov M, Uhlmann F
EMBO J
. 2024 Aug;
43(19):4173-4196.
PMID: 39160275
The ring-shaped cohesin complex topologically entraps two DNA molecules to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide-ranging implications for gene regulation, and cohesin is...
3.
Tang M, Uhlmann F
STAR Protoc
. 2024 Apr;
5(2):102995.
PMID: 38578833
To understand the transition from interphase chromatin into well-shaped chromosomes during cell divisions, we need to understand the biochemical activities of the contributing proteins. Here, we present a protocol to...
4.
Etherington G, Wu P, Oliferenko S, Uhlmann F, Nieduszynski C
Yeast
. 2024 Mar;
41(3):73-86.
PMID: 38451028
Schizosaccharomyces japonicus belongs to the single-genus class Schizosaccharomycetes, otherwise known as "fission yeasts." As part of a composite model system with its widely studied S. pombe sister species, S. japonicus...
5.
Richeldi M, Pobegalov G, Higashi T, Gmurczyk K, Uhlmann F, Molodtsov M
Nat Struct Mol Biol
. 2023 Oct;
31(1):23-31.
PMID: 37872232
Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle. Whether individual cohesins encircle both sister...
6.
Tang M, Pobegalov G, Tanizawa H, Chen Z, Rappsilber J, Molodtsov M, et al.
Mol Cell
. 2023 Oct;
83(21):3787-3800.e9.
PMID: 37820734
Condensin is a structural maintenance of chromosomes (SMC) complex family member thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants unable to extrude loops, yet proficient in...
7.
Shrestha S, Minamino M, Chen Z, Bouchoux C, Rappsilber J, Uhlmann F
Chromosoma
. 2023 May;
132(2):117-135.
PMID: 37166686
The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for faithful segregation of DNA replication products during cell divisions. Cohesion establishment is defective in...
8.
Minamino M, Bouchoux C, Canal B, Diffley J, Uhlmann F
Cell
. 2023 Jan;
186(4):837-849.e11.
PMID: 36693376
Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Cohesion establishment requires acetylation of conserved cohesin lysine residues by Eco1 acetyltransferase. Here, we explore...
9.
Munoz S, Jones A, Bouchoux C, Gilmore T, Patel H, Uhlmann F
Nat Commun
. 2022 Dec;
13(1):7698.
PMID: 36509793
The cohesin complex participates in many structural and functional aspects of genome organization. Cohesin recruitment onto chromosomes requires nucleosome-free DNA and the Scc2-Scc4 cohesin loader complex that catalyzes topological cohesin...
10.
Kakui Y, Barrington C, Kusano Y, Thadani R, Fallesen T, Hirota T, et al.
Cell Rep
. 2022 Dec;
41(10):111753.
PMID: 36476849
Mitotic chromosomes in different organisms adopt various dimensions. What defines these dimensions is scarcely understood. Here, we compare mitotic chromosomes in budding and fission yeasts harboring similarly sized genomes distributed...