Stefan Offermanns
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Explore the profile of Stefan Offermanns including associated specialties, affiliations and a list of published articles.
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288
Citations
16019
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Recent Articles
11.
Hunt J, Christiansen C, Yassin M, Hartmann B, Offermanns S, Dragsted L, et al.
Metabolites
. 2024 Jul;
14(7).
PMID: 39057718
Short-chain fatty acids (SCFAs) are the major microbial metabolites produced from the fermentation of dietary fiber in the gut. They are recognised as secretagogues of the glucagon-like peptides, GLP-1 and...
12.
Peng Y, Du J, Li R, Gunther S, Wettschureck N, Offermanns S, et al.
Cell Discov
. 2024 Jul;
10(1):76.
PMID: 39009565
Multiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental to guarantee long-term replenishment of the stem cell pool. Here, we describe that the G-proteins G-G integrate signals...
13.
Liang G, Lv X, Huang W, Jin Y, Roquid K, Kawase H, et al.
Arterioscler Thromb Vasc Biol
. 2024 Jun;
44(8):1748-1763.
PMID: 38934115
Background: Vascular smooth muscle cells (VSMCs) are highly plastic. Vessel injury induces a phenotypic transformation from differentiated to dedifferentiated VSMCs, which involves reduced expression of contractile proteins and increased production...
14.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov V, Moroz Y, et al.
J Med Chem
. 2024 Jun;
67(13):10567-10588.
PMID: 38917049
G protein-coupled receptor G2A was postulated to be a promising target for the development of new therapeutics in neuropathic pain, acute myeloid leukemia, and inflammation. However, there is still a...
15.
Wang T, Shao J, Kumar S, Alnouri M, Carvalho J, Gunther S, et al.
Circ Res
. 2024 Apr;
134(10):1259-1275.
PMID: 38597112
Background: GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C...
16.
Dorner P, Anandakumar H, Rowekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, et al.
Nat Commun
. 2024 Mar;
15(1):2788.
PMID: 38555356
Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying...
17.
Xu S, Offermanns S
Trends Endocrinol Metab
. 2024 Mar;
35(6):453-455.
PMID: 38431437
Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood...
18.
Alexander S, Christopoulos A, Davenport A, Kelly E, Mathie A, Peters J, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S23-S144.
PMID: 38123151
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
19.
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S145-S222.
PMID: 38123150
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
20.
Trif C, Banica A, Manolache A, Anghel S, Hutanu D, Stratulat T, et al.
Br J Pharmacol
. 2023 Dec;
181(9):1438-1451.
PMID: 38044577
Background And Purpose: The TRPM8 ion channel is involved in innocuous cold sensing and has a potent anti-inflammatory action. Its activation by lower temperature or chemical agonists such as menthol...