Stefan M V Freund
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Explore the profile of Stefan M V Freund including associated specialties, affiliations and a list of published articles.
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76
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3593
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Recent Articles
1.
Li X, Yu C, Gomez-Navarro N, Stancheva V, Zhu H, Murthy A, et al.
PNAS Nexus
. 2024 Jan;
3(1):pgae006.
PMID: 38269070
A number of intrinsically disordered proteins (IDPs) encoded in stress-tolerant organisms, such as tardigrade, can confer fitness advantage and abiotic stress tolerance when heterologously expressed. Tardigrade-specific disordered proteins including the...
2.
Fatalska A, Hodgson G, Freund S, Maslen S, Morgan T, Thorkelsson S, et al.
Mol Cell
. 2023 Dec;
84(3):506-521.e11.
PMID: 38159565
Regulated protein phosphorylation controls most cellular processes. The protein phosphatase PP1 is the catalytic subunit of many holoenzymes that dephosphorylate serine/threonine residues. How these enzymes recruit their substrates is largely...
3.
Lovestam S, Li D, Wagstaff J, Kotecha A, Kimanius D, McLaughlin S, et al.
Nature
. 2023 Nov;
625(7993):119-125.
PMID: 38030728
Intermediate species in the assembly of amyloid filaments are believed to play a central role in neurodegenerative diseases and may constitute important targets for therapeutic intervention. However, structural information about...
4.
Nixon-Abell J, Ruggeri F, Qamar S, Herling T, Czekalska M, Shen Y, et al.
bioRxiv
. 2023 Mar;
PMID: 36993242
Graphical Abstract:
5.
Fischer E, Yu C, Hevler J, McLaughlin S, Maslen S, Heck A, et al.
Nat Commun
. 2022 Oct;
13(1):6381.
PMID: 36289199
In response to improper kinetochore-microtubule attachments in mitosis, the spindle assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome, thereby delaying entry into anaphase. The...
6.
Nierhaus T, McLaughlin S, Burmann F, Kureisaite-Ciziene D, Maslen S, Skehel J, et al.
Nat Microbiol
. 2022 Sep;
7(10):1686-1701.
PMID: 36123441
During bacterial cell division, filaments of tubulin-like FtsZ form the Z-ring, which is the cytoplasmic scaffold for divisome assembly. In Escherichia coli, the actin homologue FtsA anchors the Z-ring to...
7.
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Elliott P, Leske D, Wagstaff J, Schlicher L, Berridge G, Maslen S, et al.
Cell Rep
. 2021 Oct;
37(1):109777.
PMID: 34610306
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase...
8.
Kumar A, Yu C, Rodriguez-Molina J, Li X, Freund S, Passmore L
Genes Dev
. 2021 Oct;
35(21-22):1510-1526.
PMID: 34593603
Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3' end processing in eukaryotes. It contains an endonuclease that cleaves pre-mRNAs, and a polymerase that adds a...
9.
Beitia G, Rutherford T, Freund S, Pelham H, Bienz M, Gammons M
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34155117
Wnt signals bind to Frizzled receptors to trigger canonical and noncanonical signaling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the...
10.
Fischer E, Yu C, Bellini D, McLaughlin S, Orr C, Wagner A, et al.
EMBO Rep
. 2021 May;
22(7):e52242.
PMID: 34013668
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex/cyclosome (APC/C). This process is orchestrated...