Dmitry B Veprintsev
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Explore the profile of Dmitry B Veprintsev including associated specialties, affiliations and a list of published articles.
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76
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3303
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Recent Articles
1.
Thorsen T, Kulkarni Y, Sykes D, Boggild A, Drace T, Hompluem P, et al.
Nat Commun
. 2025 Jan;
16(1):486.
PMID: 39779700
Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulation and sleep apnea relief. THC's psychoactive actions are mediated...
2.
Wong S, Brown A, Abrahams A, Nurzak A, Eltaher H, Sykes D, et al.
Pharmaceutics
. 2024 Oct;
16(10).
PMID: 39458599
Methods: The current research used in vitro assays for a novel exploration of PLR's ability to improve the transport of two contrasting peptides, insulin (51 residues, net negative charge) and...
3.
Aebi J, Atz K, Ametamey S, Benz J, Blaising J, Butini S, et al.
Chimia (Aarau)
. 2024 Sep;
78(7-8):499-512.
PMID: 39221845
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating...
4.
Gusach A, Lee Y, Khoshgrudi A, Mukhaleva E, Ma N, Koers E, et al.
Nat Commun
. 2024 Aug;
15(1):7555.
PMID: 39215004
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct,...
5.
Mach L, Omran A, Bouma J, Radetzki S, Sykes D, Guba W, et al.
J Med Chem
. 2024 Jul;
67(14):11841-11867.
PMID: 38990855
The cannabinoid receptor type 1 (CBR) is pivotal within the endocannabinoid system regulating various signaling cascades with effects in appetite regulation, pain perception, memory formation, and thermoregulation. Still, understanding of...
6.
Kosar M, Sarott R, Sykes D, Viray A, Vitale R, Tomasevic N, et al.
ACS Cent Sci
. 2024 May;
10(5):956-968.
PMID: 38799662
We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands with a tailored functional response. The present study discloses the structure-based design of cannabinoid receptor...
7.
Cullum S, Platt S, Dale N, Isaac O, Wragg E, Soave M, et al.
Commun Biol
. 2024 Apr;
7(1):417.
PMID: 38580813
The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation. This model...
8.
Hoare B, Tippett D, Kaur A, Cullum S, Miljus T, Koers E, et al.
Chembiochem
. 2023 Oct;
25(2):e202300459.
PMID: 37872746
Measurements of membrane protein thermostability reflect ligand binding. Current thermostability assays often require protein purification or rely on pre-existing radiolabelled or fluorescent ligands, limiting their application to established targets. Alternative...
9.
Scott-Dennis M, Rafani F, Yi Y, Perera T, Harwood C, Guba W, et al.
Front Pharmacol
. 2023 Aug;
14:1158091.
PMID: 37637423
The cannabinoid receptor (CBR) subtypes 1 (CBR) and 2 (CBR) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and...
10.
Kosar M, Sykes D, Viray A, Vitale R, Sarott R, Ganzoni R, et al.
J Am Chem Soc
. 2023 Jul;
145(28):15094-15108.
PMID: 37401816
Pharmacological modulation of cannabinoid receptor type 2 (CBR) holds promise for the treatment of neuroinflammatory disorders, such as Alzheimer's disease. Despite the importance of CBR, its expression and downstream signaling...