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Stefan Joos

Explore the profile of Stefan Joos including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 44
Citations 1722
Followers 0
Related Specialties
Oncology
Molecular Biology
Dentistry
Top 10 Co-Authors
Peter Lichter
Kolja Freier
Christof Hofele
Christa Flechtenmacher
Bernhard Radlwimmer
Gunhild Mechtersheimer
Frauke Devens
Ralf J Rieker
Axel Benner
Guido Reifenberger
Published In
Int J Cancer
Cancer Res
Genes Chromosomes Cancer
Blood
Cancer Genet Cytogenet
Affiliations
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Recent Articles
11.
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
Mathas S, Kreher S, Meaburn K, Johrens K, Lamprecht B, Assaf C, et al.
Proc Natl Acad Sci U S A . 2009 Mar; 106(14):5831-6. PMID: 19321746
Although the identification and characterization of translocations have rapidly increased, little is known about the mechanisms of how translocations occur in vivo. We used anaplastic large cell lymphoma (ALCL) with...
12.
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, et al.
J Clin Oncol . 2009 Mar; 27(10):1627-36. PMID: 19255330
Purpose: Medulloblastoma is the most common malignant brain tumor in children. Current treatment decisions are based on clinical variables. Novel tumor-derived biomarkers may improve the risk stratification of medulloblastoma patients....
13.
Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD
Grund K, Ahmadi R, Jung F, Funke V, Gdynia G, Benner A, et al.
Cancer Biol Ther . 2009 Jan; 7(12):1982-90. PMID: 19158480
Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARgamma-modulating drug Troglitazone downregulates the anti-apoptotic FLIP protein and sensitizes glioblastoma cells to...
14.
Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC)
Sticht C, Freier K, Knopfle K, Flechtenmacher C, Pungs S, Hofele C, et al.
Neoplasia . 2008 May; 10(5):462-70. PMID: 18472963
In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling was performed using a whole-transcriptome chip that contains 35,035 gene-specific 70 mere oligonucleotides...
15.
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
Pfister S, Janzarik W, Remke M, Ernst A, Werft W, Becker N, et al.
J Clin Invest . 2008 Apr; 118(5):1739-49. PMID: 18398503
The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis of DNA copy number aberrations...
16.
Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations
Martinez R, Roggendorf W, Baretton G, Klein R, Toedt G, Lichter P, et al.
Cancer Genet Cytogenet . 2007 May; 175(1):26-34. PMID: 17498554
We have comparatively analyzed mechanisms associated with chromosomal and microsatellite instability in giant cell glioblastoma multiforme (gcGBM) and classic GBM. This included microsatellite instability (MSI), loss of expression of four...
17.
Frequent high telomerase reverse transcriptase expression in primary oral squamous cell carcinoma
Freier K, Pungs S, Flechtenmacher C, Bosch F, Lichter P, Joos S, et al.
J Oral Pathol Med . 2007 Apr; 36(5):267-72. PMID: 17448136
Background: Gene copy number gain of chromosomal arm 5p is frequently found in oral squamous cell carcinoma (OSCC) suggesting the activation of proto-oncogenes. TERT is a candidate gene encoding for...
18.
High survivin expression is associated with favorable outcome in advanced primary oral squamous cell carcinoma after radiation therapy
Freier K, Pungs S, Sticht C, Flechtenmacher C, Lichter P, Joos S, et al.
Int J Cancer . 2006 Dec; 120(4):942-6. PMID: 17187360
Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior. Recent studies suggested that high expression of the antiapoptotic protein survivin might be...
19.
COX-2 upregulation in thymomas and thymic carcinomas
Rieker R, Joos S, Mechtersheimer G, Blaeker H, Schnabel P, Morresi-Hauf A, et al.
Int J Cancer . 2006 Jul; 119(9):2063-70. PMID: 16823844
The treatment of advanced stage thymomas and thymic carcinomas is a multimodal therapy. New therapeutic targets are currently under investigation, including the epidermal growth factor receptor (EGFR) as well as...
20.
Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC)
Freier K, Schwaenen C, Sticht C, Flechtenmacher C, Muhling J, Hofele C, et al.
Oral Oncol . 2006 Jun; 43(1):60-6. PMID: 16807070
Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To...