Frauke Devens
Overview
Explore the profile of Frauke Devens including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
532
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0
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Recent Articles
1.
Kats I, Simovic-Lorenz M, Schreiber H, Sant P, Mallm J, Korber V, et al.
Nat Commun
. 2024 Nov;
15(1):10370.
PMID: 39609432
Paediatric medulloblastomas with chromothripsis are characterised by high genomic instability and are among the tumours with the worst prognosis. However, the molecular makeup and the determinants of the aggressiveness of...
2.
Khalid U, Simovic M, Hammann L, Iskar M, Wong J, Kumar R, et al.
Int J Cancer
. 2022 Apr;
151(4):590-606.
PMID: 35411591
Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are...
3.
Bolkestein M, Wong J, Thewes V, Korber V, Hlevnjak M, Elgaafary S, et al.
Cancer Res
. 2020 Sep;
80(22):4918-4931.
PMID: 32973084
Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes. Widely assumed to be an early...
4.
Kolb T, Khalid U, Simovic M, Ratnaparkhe M, Wong J, Jauch A, et al.
Genes Chromosomes Cancer
. 2020 Aug;
60(5):303-313.
PMID: 32734664
In vitro assays for clustered DNA lesions will facilitate the analysis of the mechanisms underlying complex genome rearrangements such as chromothripsis, including the recruitment of repair factors to sites of...
5.
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Ratnaparkhe M, Wong J, Wei P, Hlevnjak M, Kolb T, Simovic M, et al.
Nat Commun
. 2018 Nov;
9(1):4760.
PMID: 30420702
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n = 16/26) in brain tumors developing in mice deficient for factors...
6.
Maass K, Rosing F, Ronchi P, Willmund K, Devens F, Hergt M, et al.
Exp Cell Res
. 2018 Aug;
371(2):353-363.
PMID: 30149001
Micronuclei are extra-nuclear bodies containing whole chromosomes that were not incorporated into the nucleus after cell division or damaged chromosome fragments. Even though the link between micronuclei and DNA damage...
7.
Ernst A, Jones D, Maass K, Rode A, Deeg K, Jebaraj B, et al.
Int J Cancer
. 2016 Feb;
138(12):2905-14.
PMID: 26856307
Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to...
8.
Wan F, Herold-Mende C, Campos B, Centner F, Dictus C, Becker N, et al.
Biomarkers
. 2011 Feb;
16(2):136-43.
PMID: 21323603
To study the clinical relevance of undifferentiated tumour cells in astrocytic gliomas we employed a large tumour tissue microarray (n=283) with corresponding clinical data and analyzed the expression of Nestin...
9.
Freier K, Hofele C, Knoepfle K, Gross M, Devens F, Dyckhoff G, et al.
J Oral Pathol Med
. 2010 Feb;
39(5):382-9.
PMID: 20149059
Head and neck squamous cell carcinoma (HNSCC) is a solid malignant neoplasm exhibiting aggressive phenotypes and high recurrence rates. To improve its clinical management, understanding the molecular basis of HNSCC...
10.
Freier K, Knoepfle K, Flechtenmacher C, Pungs S, Devens F, Toedt G, et al.
Genes Chromosomes Cancer
. 2009 Sep;
49(1):9-16.
PMID: 19787784
Gene copy number aberrations are involved in oral squamous cell carcinoma (OSCC) development. To delineate candidate genes inside critical chromosomal regions, array-CGH was applied to 40 OSCC specimens using a...