Stanton McHardy
Overview
Explore the profile of Stanton McHardy including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
45
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Recent Articles
1.
Pratap U, Sareddy G, Liu Z, Pitta Venkata P, Liu J, Tang W, et al.
Neurooncol Adv
. 2021 Sep;
3(1):vdab099.
PMID: 34485908
Background: Glioblastomas (GBMs) are the most lethal primary brain tumors. Estrogen receptor β (ERβ) function as a tumor suppressor in GBM, however, ERβ expression is commonly suppressed during glioma progression....
2.
Shin I, Davis I, Nieves-Merced K, Wang Y, McHardy S, Liu A
Chem Sci
. 2021 Jun;
12(11):3984-3998.
PMID: 34163669
SfmD is a heme-dependent enzyme in the biosynthetic pathway of saframycin A. Here, we present a 1.78 Å resolution crystal structure of SfmD, which unveils a novel heme cofactor attached...
3.
Bekhit M, Wang H, McHardy S, Gorski W
Anal Chem
. 2020 Feb;
92(5):3860-3866.
PMID: 32040916
The four glucosyl esters were synthesized and tested for the determination of infection enzyme leukocyte esterase (LE) in human synovial (joint) fluid and urine. The esters acted as LE substrates...
4.
Hanson D, Menard T, Blazek T, McHardy S, Gorski W
Chembiochem
. 2018 Apr;
19(14):1488-1491.
PMID: 29679431
We introduce a new class of substrates (compounds I-III) for leukocyte esterase (LE) that react with LE yielding anodic current in direct proportion to LE activity. The kinetic constants K...
5.
Blasio A, Wang J, Wang D, Varodayan F, Pomrenze M, Miller J, et al.
Biol Psychiatry
. 2017 Dec;
84(3):193-201.
PMID: 29198469
Background: Despite the high cost and widespread prevalence of alcohol use disorders, treatment options are limited, underscoring the need for new, effective medications. Previous results using protein kinase C epsilon...
6.
Hanson D, Menard T, McHardy S, Fleischman A, Gorski W
Anal Chem
. 2017 Jun;
89(14):7781-7787.
PMID: 28608672
The ester 4-((tosyl-l-alanyl)oxy)phenyl tosyl-l-alaninate (TAPTA) was synthesized and tested as a substrate for leukocyte esterase (LE), an enzyme produced by leukocytes (white blood cells). In the presence of LE, TAPTA...
7.
Yuan B, Cheng L, Gupta K, Chiang H, Gupta H, Sareddy G, et al.
Oncotarget
. 2016 Jun;
7(27):42585-42597.
PMID: 27323858
Unlike estrogen receptor α (ERα) that predominantly promotes hormone-dependent breast tumor growth, ERβ exhibits antitumor effects in a variety of cancer types. We recently identified a phosphotyrosine residue in ERβ,...