Richard Elledge
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Explore the profile of Richard Elledge including associated specialties, affiliations and a list of published articles.
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29
Citations
1205
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Recent Articles
1.
Wu B, Qi L, Chiang H, Pan H, Zhang X, Greenbaum A, et al.
J Immunother Cancer
. 2023 Feb;
11(2).
PMID: 36731891
Women with germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is...
2.
Lin C, Tan X, Chen M, Kusi M, Hung C, Chou C, et al.
BMC Med Genomics
. 2020 May;
13(1):69.
PMID: 32408897
Background: Chromothripsis is an event of genomic instability leading to complex chromosomal alterations in cancer. Frequent long-range chromatin interactions between transcription factors (TFs) and targets may promote extensive translocations and...
3.
Zhang X, Chiang H, Wang Y, Zhang C, Smith S, Zhao X, et al.
Nat Commun
. 2018 Mar;
9:16211.
PMID: 29600804
This corrects the article DOI: 10.1038/ncomms15908.
4.
Williams M, Lee L, Werfel T, Joly M, Hicks D, Rahman B, et al.
Cell Death Dis
. 2018 Jan;
9(2):21.
PMID: 29343814
Estrogen receptor-α positive (ERα+) breast cancer accounts for approximately 70-80% of the nearly 25,0000 new cases of breast cancer diagnosed in the US each year. Endocrine-targeted therapies (those that block...
5.
Zhang X, Chiang H, Wang Y, Zhang C, Smith S, Zhao X, et al.
Nat Commun
. 2017 Jun;
8:15908.
PMID: 28649985
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it...
6.
Yuan B, Cheng L, Gupta K, Chiang H, Gupta H, Sareddy G, et al.
Oncotarget
. 2016 Jun;
7(27):42585-42597.
PMID: 27323858
Unlike estrogen receptor α (ERα) that predominantly promotes hormone-dependent breast tumor growth, ERβ exhibits antitumor effects in a variety of cancer types. We recently identified a phosphotyrosine residue in ERβ,...
7.
Zoghi B, Elledge R
Breast J
. 2016 Jan;
22(2):218-23.
PMID: 26748605
Leptomeningeal disease is an uncommon complication of estrogen receptor positive breast cancer. While there is little consensus on the standard of care, recommendations from current clinical practice guidelines are to...
8.
Ha C, Michalek J, Elledge R, Kelly K, Ganapathy S, Su H, et al.
Mol Oncol
. 2015 Oct;
10(1):148-56.
PMID: 26440706
p53 activation is a primary mechanism underlying pathological responses to DNA damaging agents such as chemotherapy and radiotherapy. Our recent animal studies showed that low dose arsenic (LDA)-induced transient p53...
9.
Chiang H, Elledge R, Larson P, Jatoi I, Li R, Hu Y
Breast Cancer (Auckl)
. 2015 Jun;
9:25-9.
PMID: 26052229
Women carrying BRCA1 and BRCA2 mutations have significantly elevated risk of developing breast and ovarian cancers. BRCA1-associated breast cancer likely originates from progenitors of the luminal epithelial lineage. Recent studies...
10.
Niravath P, Tham Y, Wang T, Rodriguez A, Foreman C, Hilsenbeck S, et al.
Oncologist
. 2014 Nov;
20(1):13.
PMID: 25378456
Background: Brain metastasis from breast cancer presents a significant threat to women's health and quality of life. Capecitabine and sunitinib have shown some activity in this setting; therefore, we conducted...