Stanley Chamberlain
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Explore the profile of Stanley Chamberlain including associated specialties, affiliations and a list of published articles.
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8
Citations
121
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Recent Articles
1.
Chamberlain S, Gabriel H, Strittmatter W, Didsbury J
J Alzheimers Dis
. 2019 Dec;
73(3):1085-1103.
PMID: 31884472
Background: T3D-959 is a chemically unique, brain penetrant, dual PPAR delta/gamma agonist with 15-fold higher PPAR delta selectivity. Ubiquitous brain expression of PPAR delta, its critical role in regulating glucose...
2.
McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, et al.
Eur J Med Chem
. 2013 Nov;
70:326-40.
PMID: 24177359
We herein report the application of the phosphorodiamidate phosphate prodrug approach to a series of thirteen nucleoside analogs with antiviral or anticancer activity. Twenty-five symmetrical phosphorodiamidates were synthesized, bearing esterified...
3.
Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, et al.
Bioorg Med Chem Lett
. 2013 Mar;
23(7):2260-4.
PMID: 23453067
7-Deazapurines are known to possess broad antiviral activity, however the 2'-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV)...
4.
McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, et al.
J Med Chem
. 2011 Nov;
54(24):8632-45.
PMID: 22039920
We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2'-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and...
5.
McGuigan C, Madela K, Aljarah M, Gilles A, Battina S, Ramamurty C, et al.
Bioorg Med Chem Lett
. 2011 Aug;
21(19):6007-12.
PMID: 21856153
We have previously reported the power of combining a 5'-phosphoramidate ProTide, phosphate pro-drug, motif with a 6-methoxy purine pro-drug entity to generate highly potent anti-HCV agents, leading to agents in...
6.
Vernachio J, Bleiman B, Bryant K, Chamberlain S, Hunley D, Hutchins J, et al.
Antimicrob Agents Chemother
. 2011 Mar;
55(5):1843-51.
PMID: 21357300
INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h....
7.
McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(16):4850-4.
PMID: 20637609
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic...
8.
McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, et al.
J Med Chem
. 2010 Jun;
53(13):4949-57.
PMID: 20527890
Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy, and selectivity are recognized as likely key components of...